AIF Cancer Research Results

AIF, Apoptosis-Inducing Factor: Click to Expand ⟱
Source:
Type:
AIF is a mitochondrial oxidoreductase that contributes to cell death programmes and participates in the assembly of the respiratory chain.
Nuclear translocation of AIF occurs during cell death and has been associated with human disorders. Expression Levels:
AIF is often found to be overexpressed in several types of cancers, including breast, lung, and colorectal cancers.
The expression of AIF can vary significantly between different tumor types and even among patients with the same type of cancer.
Survival Rates:
High levels of AIF expression have been associated with poor prognosis in certain cancers, indicating a potential role in tumor aggressiveness and metastasis.
Conversely, low AIF expression may correlate with better survival outcomes in some contexts.
Overexpression: In many cancers, AIF is overexpressed, which is often associated with poor prognosis, increased tumor aggressiveness, and resistance to therapy.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, NA, NA
RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↓, 1,   GSH↓, 2,   lipid-P↑, 1,   ROS↑, 3,   ROS⇅, 1,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 3,   MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

RNR↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BIM↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   IAP1↓, 1,   IAP2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   GADD45A↑, 1,   p‑P53↑, 1,   p‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   STAT3↓, 1,   TumCG↑, 1,  

Migration ⓘ

MMP9↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↓, 1,   eff↑, 1,   selectivity↓, 1,   selectivity↑, 2,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   MPO↑, 1,   SOD↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   neuroP↑, 1,   radioP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: AIF, Apoptosis-Inducing Factor
1 Apigenin (mainly Parsley)
1 Metformin
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:520  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page