mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱
Source:
Type:
Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
342- AgNPs,    Silver nanoparticles; a new hope in cancer therapy?
- Review, NA, NA
ROS↑, DNAdam↑, Apoptosis↑, mtDam↑,
375- AgNPs,  ALA,    Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,
367- AgNPs,    Presence of an Immune System Increases Anti-Tumor Effect of Ag Nanoparticle Treated Mice
- in-vivo, NA, NA
ROS↑, mtDam↑, TumCG↓,
393- AgNPs,    Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity
- in-vitro, NA, HCT116
mtDam↑, ROS↑, TumCCA↑, Casp3↑, BAX↑, Bcl-2↓, P53↑,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, NA, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, NA, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP↝, p‑ATF4↝, cl‑Casp12↝,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,

Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   H2O2↑, 2,   Iron↑, 1,   ROS?, 1,   ROS↑, 10,   mt-ROS↑, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 3,   MMP↑, 1,   MPT↓, 1,   mtDam↑, 13,  

Core Metabolism/Glycolysis ⓘ

ATG7↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   PFKP↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 5,   BAX↑, 4,   Bcl-2↓, 3,   cl‑Casp12↝, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Cupro↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   GSDME-N↑, 1,   Necroptosis↑, 1,   Paraptosis↑, 1,   Pyro↑, 2,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV?, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑CHOP↝, 1,   p‑eIF2α↝, 1,   ER Stress↑, 2,   p‑PERK↝, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   BNIP3↝, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   P53↑, 3,   p‑P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   FOXO↓, 1,   IGFR↓, 1,   STAT1↓, 1,   STAT3↓, 1,   TumCG↓, 3,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCP↓, 3,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

p‑ATF4↝, 1,   EGFR↓, 1,   Hif1a↓, 1,   NO↑, 1,   PDGFR-BB↑, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

CellMemb↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   ChemoSen↑, 2,   Dose↝, 1,   Dose∅, 1,   eff↓, 2,   eff↑, 5,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 89

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

MDA↓, 1,   ROS↓, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   TNF-α↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 2,  
Total Targets: 6

Scientific Paper Hit Count for: mtDam, mitochondrial damage
4 Silver-NanoParticles
2 Honokiol
1 Alpha-Lipoic-Acid
1 Berberine
1 Radiotherapy/Radiation
1 Carvacrol
1 Copper and Cu NanoParticles
1 EGCG (Epigallocatechin Gallate)
1 Gambogic Acid
1 Luteolin
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:614  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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