CREB Cancer Research Results

CREB, cAMP Response Element Binding Protein: Click to Expand ⟱
Source:
Type: transcription factor
CREB is a transcription factor that binds to specific DNA sequences, known as cAMP response elements (CRE), in the promoter regions of target genes.
CREB is activated by phosphorylation, which allows it to bind to CRE and recruit other transcriptional coactivators.
CREB regulates the expression of genes involved in various cellular processes, including:
    Cell growth and differentiation
    Apoptosis
    Metabolism
    Neurotransmission

CREB is also involved in the regulation of genes involved in cancer, including:
    Cell cycle progression
    Angiogenesis
    Invasion and metastasis

CREB is often overexpressed in cancer tissues.
High levels of CREB expression are associated with poor prognosis, increased tumor aggressiveness, and resistance to therapy. CREB can promote the expression of genes involved in cell survival and proliferation.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
4279- Api,    The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations
- Review, NA, NA
*antiOx↑, *Inflam↓, *BBB↑, *5HT↑, *CREB↑, *BDNF↑, *memory↑, *motorD↑, *Mood↑, *cognitive↑, *ROS↓,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, NA, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
4277- BM,    Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri
- in-vivo, NA, NA
*BDNF↑, *p‑CREB↑,
4260- CHr,    Chrysin modulates the BDNF/TrkB/AKT/Creb neuroplasticity signaling pathway: Acting in the improvement of cognitive flexibility and declarative, working and aversive memory deficits caused by hypothyroidism in C57BL/6 female mice
- in-vivo, NA, NA
*BDNF↑, *TrkB↑, *Akt↑, *CREB↑, *memory↑, *cognitive↑,
4208- Cro,    Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus
- in-vivo, NA, NA
*BDNF↑, *CREB↑, *p‑CREB↑,
4171- CUR,    Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons
- in-vivo, NA, NA
*BDNF↑, *TrkB↑, *CREB↑, *Mood↑, *neuroP↑,
4178- DHA,    The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma
- in-vivo, NA, NA
*BDNF↑, *CREB↑, *cognitive↑, *SOD↑,
4177- DHA,    Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats
- in-vivo, NA, NA
*BDNF↑, *CREB↑, *ROS↓, *cognitive↑,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, NA, NA
*ERK↑, *BDNF↑, *CREB↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, NA, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, NA, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 2,   Iron↓, 1,   MDA↓, 2,   ROS↓, 4,   SOD↓, 1,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   TfR1/CD71↓, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 11,   p‑CREB↑, 2,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   Casp3↓, 1,   iNOS↑, 1,   JNK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 3,  

Migration ⓘ

PKA↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 11,   BDNF∅, 1,   ChAT↑, 1,   PSD95↑, 1,   TrkB↑, 3,  

Clinical Biomarkers ⓘ

CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 5,   memory↑, 3,   Mood↑, 2,   motorD↑, 1,   neuroP↑, 3,  
Total Targets: 38

Scientific Paper Hit Count for: CREB, cAMP Response Element Binding Protein
2 Docosahexaenoic Acid
1 Apigenin (mainly Parsley)
1 Berberine
1 Bacopa monnieri
1 Chrysin
1 Crocetin
1 Curcumin
1 flavonoids
1 Huperzine A/Huperzia serrata
1 Safflower yellow
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:798  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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