ATF6 Cancer Research Results

ATF6, Activating Transcription Factor 6: Click to Expand ⟱
Source:
Type: protein
ATF6 (Activating Transcription Factor 6) is a protein that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway that is activated in response to endoplasmic reticulum (ER) stress.
High ATF6 expression is associated with poor prognosis, including shorter overall survival and increased risk of recurrence.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
2860- FIS,    Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3 - in-vitro, Nor, hTERT-HPNE - in-vivo, NA, NA
AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 1,   MDA↑, 1,   NRF2↑, 1,   ROS↑, 1,   SAM-e↝, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑MEK↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   NAD↝, 1,   PI3K/Akt↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp12↑, 1,   Casp3↑, 2,   Casp9↑, 2,   Cyt‑c↑, 1,   JNK↓, 1,   MAPK↝, 1,   p38↑, 1,   TumCD↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   GRP94↑, 1,   PERK↑, 1,   UPR↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Cyc↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BRAF↝, 1,   ERK↑, 1,   p‑ERK↓, 1,   IGF-1↓, 1,   mTOR↑, 1,   PTEN↝, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1↓, 1,   IL6↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRAF↝, 1,   IL6↓, 1,   PSA↓, 1,  
Total Targets: 53

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF6, Activating Transcription Factor 6
1 Boron
1 Fisetin
1 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:861  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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