Necroptosis Cancer Research Results

Necroptosis, Necroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Necroptosis, is a form of programmed cell death that is regulated by the cell's own mechanisms. It is a form of cell death that is mediated by specific signaling pathways, including the RIP1-RIP3-MLKL pathway. Necroptosis is characterized by the activation of specific enzymes, such as RIP1 and RIP3, which lead to the formation of a necroptotic complex that ultimately causes cell death.

Necroptosis expression can be elevated in certain types of cancer, it can also be reduced in other types of cancer.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, NA, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
2222- SK,    The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis
- in-vitro, OS, U2OS - in-vitro, OS, 143B - in-vivo, NA, NA
Necroptosis↑, RIP1↑, RIP3↑, OS↑, P53↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 5,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 1,   MPT↓, 1,   mtDam↑, 1,  

Cell Death ⓘ

Apoptosis↑, 4,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MAPK↑, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 5,   p38↑, 1,   RIP1↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   p‑P53↑, 1,   p‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   ERK↑, 1,   TumCG↑, 1,  

Migration ⓘ

Ca+2↑, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   Dose∅, 1,   eff↓, 2,   eff↑, 1,   RadioS↑, 1,   selectivity↓, 1,   selectivity↑, 3,  

Functional Outcomes ⓘ

OS↑, 1,   TumW↓, 1,  
Total Targets: 50

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Wnt↑, 1,  

Migration ⓘ

Ca+2↑, 1,   FAK↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: Necroptosis, Necroptosis
1 Apigenin (mainly Parsley)
1 Metformin
1 Carvacrol
1 Magnetic Fields
1 Piperine
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:944  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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