eff Cancer Research Results
eff, efficacy: Click to Expand ⟱
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| Type: |
Power to enhance an anti cancer effect
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NA, Not Available: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
CRC, |
HT29 |
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in-vivo, |
NA, |
NA |
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eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
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in-vitro, |
Var, |
A549 |
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in-vitro, |
NA, |
HCT116 |
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in-vitro, |
NA, |
HeLa |
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in-vitro, |
NA, |
HepG2 |
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in-vitro, |
NA, |
HT1080 |
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in-vitro, |
NA, |
PC3 |
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- |
in-vitro, |
NA, |
SH-SY5Y |
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TumCP↓, other↝, eff↝, mt-UPR↑,
other↓, ROS↑, MMP↓, eff↝,
HSPs∅, *HSPs↑, eff↝, *eff↑, eff↑, eff↓,
*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
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in-vitro, |
NA, |
A549 |
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in-vitro, |
NA, |
LoVo |
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TumCP↓, eff↝,
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in-vitro, |
GBM, |
U87MG |
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NA, |
NA, |
U251 |
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RadioS↑, eff↝, P53↝,
*eff↑, *eff↝,
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
Showing Research Papers: 1 to 12 of 12
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
NRF2↓, 1, ROS↓, 1, ROS↑, 6, SOD↑, 1,
Mitochondria & Bioenergetics ⓘ
ATP↓, 1, MMP↓, 2,
Core Metabolism/Glycolysis ⓘ
AMPK↑, 1, SIRT1↓, 1, SIRT1↑, 1, SREBP1↓, 1,
Cell Death ⓘ
Akt↓, 1, p‑Akt↓, 1, Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp↑, 1, Cyt‑c↑, 1, p27↑, 1, Telomerase↓, 1,
Transcription & Epigenetics ⓘ
HATs↑, 1, other↓, 1, other↝, 1,
Protein Folding & ER Stress ⓘ
HSP70/HSPA5↑, 1, HSPs∅, 1, mt-UPR↑, 1,
DNA Damage & Repair ⓘ
DNAdam↑, 2, P53↝, 1,
Cell Cycle & Senescence ⓘ
CDK4↓, 1, P21↑, 1, TumCCA↑, 2,
Proliferation, Differentiation & Cell State ⓘ
CD44↓, 1, EMT↓, 1, ERK↓, 1, HDAC↓, 1, IGF-1↓, 1, IGFBP3↑, 1, mTOR↓, 1, NOTCH↓, 1, PI3K↑, 1, STAT3↓, 1, TOP1↝, 1, TumCG↓, 2, Wnt↓, 1,
Migration ⓘ
CA↓, 1, Ca+2↑, 2, E-cadherin↑, 1, FAK↓, 1, miR-203↑, 1, MMP2↓, 1, MMP9↓, 1, PDGF↓, 1, TGF-β↓, 1, TumCMig↓, 1, TumCP↓, 2, uPA↓, 1, Vim↓, 1, Zeb1↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, EGFR↓, 1, Hif1a↓, 2, VEGF↓, 2,
Barriers & Transport ⓘ
NHE1↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, IL1↓, 1, NF-kB↓, 1, PD-L1↓, 1, PGE2↓, 1, PSA↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 3, Dose↝, 1, eff↓, 1, eff↑, 3, eff↝, 10, Half-Life↓, 1, Half-Life↝, 1, RadioS↑, 2, selectivity↑, 2,
Clinical Biomarkers ⓘ
AR↓, 1, EGFR↓, 1, GutMicro↑, 1, PD-L1↓, 1, PSA↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, cardioP↑, 1, chemoP↑, 1, hepatoP↑, 1, OS↑, 2, Risk↓, 1, toxicity↓, 2, toxicity↝, 1, toxicity∅, 1,
Total Targets: 92
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1,
Core Metabolism/Glycolysis ⓘ
SIRT1↑, 1,
Cell Death ⓘ
HEY1↑, 1, MAPK↑, 1, p38↑, 1,
Transcription & Epigenetics ⓘ
other↑, 1,
Protein Folding & ER Stress ⓘ
HSPs↑, 1,
DNA Damage & Repair ⓘ
DNArepair↑, 1,
Cell Cycle & Senescence ⓘ
E2Fs↑, 1,
Proliferation, Differentiation & Cell State ⓘ
NOTCH↑, 1,
Migration ⓘ
MMP2↑, 1, MMP9↑, 1, TIMP1↓, 1, TIMP1↑, 1,
Angiogenesis & Vasculature ⓘ
Hif1a↑, 1, VEGF↑, 1,
Immune & Inflammatory Signaling ⓘ
IL8↓, 1, Inflam↓, 1,
Drug Metabolism & Resistance ⓘ
eff↓, 1, eff↑, 3, eff↝, 2,
Total Targets: 21
Scientific Paper Hit Count for: eff, efficacy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:0 Cells:% prod#:% Target#:961 State#:% Dir#:4
wNotes=0 sortOrder:rid,rpid
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