PYCR1 Cancer Research Results

PYCR1, Pyrroline-5-Carboxylate Reductase 1: Click to Expand ⟱
Source:
Type:
Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is an enzyme that catalyzes the final step in proline biosynthesis by reducing pyrroline-5-carboxylate to proline. This enzyme plays an integral role in cellular metabolism and redox balance. In the context of cancer, PYCR1 has emerged as a notable factor, with its expression levels often correlating with tumor progression and patient prognosis.

-Numerous studies have found that PYCR1 is overexpressed in a variety of tumor types, including breast cancer, lung cancer, liver cancer, and others.
Elevated PYCR1 expression is thought to provide tumor cells with a survival advantage by contributing to anabolic metabolism and helping to mitigate oxidative stress.
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
2224- SK,    Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
PYCR1↓, PI3K↓, Akt↓, mTOR↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PYCR1↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PYCR1, Pyrroline-5-Carboxylate Reductase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:1158  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page