TRPV1 Cancer Research Results

TRPV1, transient receptor potential vanilloid 1: Click to Expand ⟱
Source:
Type:
TRPV1 is a ligand-gated ion channel classically associated with nociception and heat sensation.
- TRPV1 is a nonselective cation channel that allows the influx of calcium (and other cations) when activated by various stimuli such as capsaicin, heat, or low pH.
- TRPV1 can influence key cellular processes including proliferation, apoptosis, and migration by modulating intracellular calcium levels and downstream signaling cascades.

- In some cases, TRPV1 activation can induce cell death, which might translate into less aggressive tumor behavior; however, this is not a universal finding.
- TRPV1 is a non-selective cation channel, which is frequently overexpressed in highly malignant cancers.
- Capsaicin may be able to induce cell death in urothelial cancer and glioma cells via TRPV1-dependent stimulation of excessive calcium (Ca2+) influx
- Activation of TRPV1 promotsd the generation of ROS.
- Variability in TRPV1 expression and function suggests that it might serve as one component of a broader prognostic panel rather than a standalone marker.
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   TRPV1↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   p‑STAT3↑, 1,  

Migration ⓘ

Ca+2↑, 1,   MMP2↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,   selectivity↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRPV1, transient receptor potential vanilloid 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:1227  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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