PINK1 Cancer Research Results

PINK1, PTEN-induced kinase 1: Click to Expand ⟱
Source:
Type:
PINK1 (PTEN-induced kinase 1) is a mitochondrial kinase that plays a critical role in maintaining mitochondrial quality control through mitophagy.
- Many studies indicate that lower PINK1 expression tends to correlate with more aggressive disease and poorer prognosis—likely due to compromised mitochondrial quality control.
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
7438- CYN,    Cynaropicrin Suppresses Cell Proliferation by Inducing Mitophagy through p38 MAPK-Mediated Mitochondrial ROS Generation in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, NA
tumCV↓, TumAuto↑, selectivity↑, mt-ROS↑, MMP↓, LC3B↑, Beclin-1↓, p62↓, PINK1↑, PARK2↑, eff↓, p‑MAPK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

PARK2↑, 1,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   PINK1↑, 1,  

Cell Death(tgid=5) ⓘ

p‑MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3B↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   selectivity↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PINK1, PTEN-induced kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:1239  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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