NQO1 Cancer Research Results

NQO1, NAD(P)H quinone dehydrogenase 1: Click to Expand ⟱

Source:

Type:

NQO1 has attracted interest due to its roles in cell defense and marked inducibility during cellular stress. Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
NQO1 (NAD(P)H:quinone oxidoreductase 1) is an enzyme that plays a significant role in cellular defense against oxidative stress and the metabolism of various compounds, including quinones and other electrophiles. Its function is crucial in protecting cells from damage caused by reactive oxygen species (ROS) and in the detoxification of potentially harmful substances.

HCC, Hepatocellular Carcinoma: Click to Expand ⟱

Hepatocellular Carcinoma

Scientific Papers found: Click to Expand⟱

5015-

Xan,

PEITC,

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

in-vitro,

HCC,

HepG2

NRF2↓, ROS↑, NF-kB↓, COX2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

NQO1↑, 1, NRF2↓, 1, NRF2↑, 1, ROS↑, 1, SOD↑, 1,

Cell Death ⓘ

Apoptosis↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, NF-kB↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: NQO1, NAD(P)H quinone dehydrogenase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells