Bcl-2 Cancer Research Results
Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
| Source: HalifaxProj (inhibit)
CGL-Driver Genes |
| Type: Antiapoptotic
Oncogene |
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
|
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↑, 1,
Cell Death ⓘ
Apoptosis↑, 1, Bcl-2↑, 1,
Autophagy & Lysosomes ⓘ
LC3II↑, 1, TumAuto↑, 1,
DNA Damage & Repair ⓘ
cl‑PARP↑, 1,
Proliferation, Differentiation & Cell State ⓘ
STAT3↑, 1,
Drug Metabolism & Resistance ⓘ
eff↓, 1, eff↑, 1,
Functional Outcomes ⓘ
AntiCan↓, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:10 Cells:% prod#:% Target#:27 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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