DR5 Cancer Research Results

DR5, Death receptor 5: Click to Expand ⟱
Source:
Type:
A protein reported to play an important role in sensitizing cancer cells to apoptosis. Death Receptor 5 (DR5), also known as TRAIL receptor 2, is a member of the tumor necrosis factor (TNF) receptor superfamily. It plays a crucial role in the apoptosis (programmed cell death) pathway, particularly in the context of cancer.
DR5 is often overexpressed in various types of tumors, including breast, colon, and lung cancers. This overexpression can make cancer cells more susceptible to TRAIL-induced apoptosis.
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
2479- Ba,    Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells
- in-vitro, HCC, SW480 - in-vitro, Pca, PC3
12LOX↓, DR5↑, CHOP/DDIT3↑, ROS↑, *ROS∅, selectivity↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CXCR3↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   DR4↑, 1,   DR5↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HRAS↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   KRAS↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,   KRAS↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Bil↓, 1,   GPx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS∅, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,  

Migration(tgid=13) ⓘ

CEA↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↓, 1,   CEA↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: DR5, Death receptor 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:88  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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