eff Cancer Research Results

eff, efficacy: Click to Expand ⟱
Source:
Type:
Power to enhance an anti cancer effect
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
5259- 3BP,    Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
- in-vivo, HCC, NA
ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5693- BRU,    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
- in-vivo, HCC, NA
NRF2↓, eff↑, p‑MAPK↑, p‑Akt↑, p‑ERK↑, p‑JNK↑,
5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, miR-126↑, Ki-67↓, PI3K↓, mTOR↓, Akt↑, eff↑, Casp3↑,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- NA, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
2018- CAP,  MF,    Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma
- Review, HCC, NA
TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,
5891- CAR,  SRF,    Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7
- in-vivo, HCC, NA
eff↑, OS↑, hepatoP↑, AFP↓, NOTCH↓, cycD1/CCND1↓, Bcl-xL↑, Casp3↑, TRPM7↓, Dose↝,
6065- CHL,    Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin
- Review, HCC, NA
*eff↑, *chemoPv↑, *other↝,
6103- Chol,    Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice
- in-vivo, HCC, NA
AntiTum↑, eff↑,
6124- CHr,  EGCG,    The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
- in-vitro, HCC, HepG2
TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, eff↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
3202- EGCG,    Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity
- in-vitro, Cerv, HeLa - in-vitro, HCC, QGY-7703
PARP16↓, p‑PERK↓, Apoptosis↑, eIF2α↓, UPR↓, ER Stress↑, eff↑, GRP78/BiP↓,
2487- metroC,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
5611- NaHCO3,    NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
- vitro+vivo, HCC, HepG2
tumCV↓, TumCG↓, pH↑, eff↑, Imm↑,
5605- NaHCO3,    A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis
- Trial, HCC, NA
eff↑, Dose↝, other↓, OS↑, toxicity↓, AntiCan↓,
4726- Se,  Oxy,    Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma
- in-vivo, HCC, NA
eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,
2224- SK,    Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
PYCR1↓, PI3K↓, Akt↓, mTOR↓, eff↑,
2101- TQ,    HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma: an approach to study anti-cancer potential
- Study, HCC, NA
HDAC↓, eff↑, eff↑, AntiCan↑,

Showing Research Papers: 1 to 18 of 18

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Ferroptosis↑, 1,   HO-1↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P↑, 1,   NRF2↓, 2,   NRF2↝, 1,   PYCR1↓, 1,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 4,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↑, 2,   cl‑Casp7↑, 1,   Ferroptosis↑, 1,   p‑JNK↑, 1,   MAPK↑, 1,   p‑MAPK↑, 1,   p‑p38↑, 1,   Proteasome↓, 1,   TRPV1↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   p‑PERK↓, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p‑p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   p‑ERK↑, 1,   HDAC↓, 1,   mTOR↓, 3,   NOTCH↓, 1,   PI3K↓, 2,   STAT3↑, 1,   p‑STAT3↑, 1,   TRPM7↓, 1,   TumCG↓, 2,  

Migration ⓘ

Ca+2↑, 1,   Ki-67↓, 1,   MMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   miR-126↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   NF-kB↑, 1,   NK cell↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,   pH∅, 1,   e-pH↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 6,   eff↓, 2,   eff↑, 21,   eff↝, 3,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AFP↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 2,   AntiCan↑, 1,   AntiTum↑, 2,   hepatoP↑, 1,   OS↑, 2,   PARP16↓, 1,   toxicity↓, 6,   toxicity↑, 2,   TumVol↓, 1,  
Total Targets: 94

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↝, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: eff, efficacy
3 Capsaicin
2 3-bromopyruvate
2 EGCG (Epigallocatechin Gallate)
2 Bicarbonate(Sodium)
1 brusatol
1 Magnetic Fields
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Chlorophyllin
1 Choline
1 Chrysin
1 Disulfiram
1 Copper and Cu NanoParticles
1 metronomic chemo
1 Selenium
1 Oxygen, Hyperbaric
1 Shikonin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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