NPL4 Cancer Research Results

NPL4, NPLOC4: Click to Expand ⟱
Source:
Type:

NPL4 is not an enzyme itself. It is a ubiquitin-recognition adaptor that works with UFD1 and VCP/p97 to extract ubiquitinated proteins from membranes, chromatin and protein complexes for processing or proteasomal degradation. It is involved in ER-associated degradation, DNA replication, DNA repair and mitotic functions.

In cancer, NPL4/NPLOC4 is generally considered tumour-promoting when increased or active.

Disulfiram modulates NPL4 in the inhibitory direction:

Disulfiram + copper → NPL4 aggregation/immobilization → NPL4 function ↓

More precisely, disulfiram is converted to diethyldithiocarbamate, which complexes with copper to form CuET [Cu(DDC)₂]. 
CuET binds to NPL4 and causes it to cluster into insoluble aggregates. 
This disables NPL4 as an adaptor of the VCP/p97–UFD1–NPL4 segregase complex


HNSCC, Head and Neck Squamous Cell Carcinoma: Click to Expand ⟱
Head and Neck Squamous Cell Carcinoma
Scientific Papers found: Click to Expand⟱
6742- DSF,    Localized Sustained Release of Copper Enhances Anti-Tumor Effects of Disulfiram in Head and Neck Cancer
- in-vitro, HNSCC, NA
TumCG↓, NPL4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NPL4↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NPL4, NPLOC4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:13  Cells:%  prod#:%  Target#:1526  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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