GSTP1/GSTπ Cancer Research Results

GSTP1/GSTπ, Glutathione S-transferase pi 1: Click to Expand ⟱
Source:
Type:
An enzyme that plays a crucial role in the detoxification of various substances, including carcinogens. It is also involved in the regulation of cellular processes, such as cell growth, differentiation, and apoptosis.
GSTP1 is overexpressed in various types of cancer, including prostate, breast, lung, and colon cancer. The overexpression of GSTP1 has been associated with cancer progression, metastasis, and poor prognosis.
HNSCC, Head and Neck Squamous Cell Carcinoma: Click to Expand ⟱
Head and Neck Squamous Cell Carcinoma
Scientific Papers found: Click to Expand⟱
1941- PL,    Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
- in-vitro, HNSCC, NA
selectivity↑, eff↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 1,   ROS↑, 1,  

Cell Death ⓘ

PUMA↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSSG∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: GSTP1/GSTπ, Glutathione S-transferase pi 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:13  Cells:%  prod#:%  Target#:601  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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