Endon Cancer Research Results

Endon, endonuclease: Click to Expand ⟱
Source:
Type:
Endonucleases are enzymes that play a crucial role in the maintenance of genome stability by cleaving the phosphodiester backbone of DNA. In the context of cancer, endonucleases can have both tumor-suppressing and tumor-promoting effects.

1. APEX1 (Apurinic/Apyrimidinic Endonuclease 1)
Cancers: Breast cancer, lung cancer, colorectal cancer Prognosis: High expression is often associated with poor prognosis due to its role in DNA repair and resistance to chemotherapy.
2. FEN1 (Flap Endonuclease 1)
Cancers: Breast cancer, prostate cancer, pancreatic cancer
Prognosis: Overexpression is linked to increased tumor aggressiveness and poor survival rates.
3. EXO1 (Exonuclease 1)
Cancers: Colorectal cancer, ovarian cancer
Prognosis: High levels of EXO1 expression can correlate with poor prognosis and increased risk of metastasis.
4. DNase I (Deoxyribonuclease I)
Cancers: Various solid tumors
Prognosis: Altered expression levels can be indicative of tumor progression and immune evasion. 5. Caspase-3 (an endonuclease involved in apoptosis)
Cancers: Various cancers, including leukemia and solid tumors
Prognosis: High levels of active caspase-3 are often associated with increased apoptosis and may correlate with better treatment responses.
6. Rad51 (a recombinase with endonuclease activity)
Cancers: Breast cancer, ovarian cancer
Prognosis: Elevated expression is often linked to resistance to DNA-damaging therapies and poor prognosis.
7. MRE11 (part of the MRN complex)
Cancers: Breast cancer, lung cancer
Prognosis: Altered expression can indicate defects in DNA repair mechanisms, influencing treatment outcomes.
8. TDP1 (Tyrosyl-DNA Phosphodiesterase 1)
Cancers: Glioblastoma, breast cancer
Prognosis: High expression levels may be associated with resistance to certain chemotherapeutic agents.
9. UNG (Uracil-DNA Glycosylase)
Cancers: Colorectal cancer, lung cancer
Prognosis: Its expression can influence the mutation rate and may correlate with tumor aggressiveness.
10. LIG3 (DNA Ligase III)
Cancers: Various cancers, including breast and prostate cancer
Prognosis: Overexpression may be linked to enhanced DNA repair capabilities, contributing to treatment resistance.
HNSCC, Head and Neck Squamous Cell Carcinoma: Click to Expand ⟱
Head and Neck Squamous Cell Carcinoma
Scientific Papers found: Click to Expand⟱
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MMP↓, 1,  

Cell Death ⓘ

Cyt‑c↑, 1,   Endon↑, 1,   iNOS↓, 1,   JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,  

Protein Folding & ER Stress ⓘ

HSPs↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   FOXO3↑, 1,   PI3K↓, 1,   RAS↓, 1,  

Migration ⓘ

Ca+2↑, 1,   FAK↓, 1,   MMP-10↓, 1,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   ROCK1↑, 1,   uPA↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,   p65↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Endon, endonuclease
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:13  Cells:%  prod#:%  Target#:635  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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