NOTCH1 Cancer Research Results

NOTCH1, Notch homolog 1, translocation-associated (Drosophila): Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
NOTCH1 is a gene that encodes a protein involved in the Notch signaling pathway, which plays a crucial role in cell differentiation, proliferation, and apoptosis.
Overall, the expression of NOTCH1 in cancer is complex and can have different implications depending on the tumor type and microenvironment.
Notch1 is a transmembrane receptor involved in the Notch signaling pathway, a highly conserved mechanism that regulates cell differentiation, proliferation, and apoptosis.

– Activation occurs following interaction with membrane-bound ligands (e.g., Jagged and Delta-like proteins) on adjacent cells, leading to proteolytic cleavage and release of the Notch intracellular domain (NICD).
Notch1 expression can be upregulated or activated in many types of cancers, including T‑cell acute lymphoblastic leukemia (T‑ALL), breast cancer, and certain solid tumors.

– In other contexts, such as in some squamous cell carcinomas and cancers of the colon, Notch1 signaling can be reduced, suggesting a dual role depending on the tissue of origin and tumor microenvironment.
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   c-Iron↑, 1,   lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

TumCP↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,   IL12↑, 1,   IL2↑, 1,   Imm↑, 1,   PD-L1↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↑, 3,   eff↑, 2,   MDR1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   QoL↑, 1,  
Total Targets: 43

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NOTCH1, Notch homolog 1, translocation-associated (Drosophila)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:221  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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