MDSCs Cancer Research Results

MDSCs, Myeloid-derived suppressor cells: Click to Expand ⟱
Source:
Type:
Myeloid-derived suppressor cells (MDSCs) are a type of immune cell that plays a significant role in cancer progression and immune evasion. They are a heterogeneous group of cells that are characterized by their ability to suppress the immune response, particularly the activity of T cells.

MDSCs are typically found in the tumor microenvironment and are thought to be recruited to the tumor site by various factors, including tumor-derived cytokines and chemokines. Once at the tumor site, MDSCs can suppress the immune response in several ways, including:
-Inhibiting the activation and proliferation of T cells.
-Suppressing the production of cytokines and chemokines that are necessary for an effective immune response.
-Inducing the production of anti-inflammatory cytokines that promote tumor growth and survival.
-Inhibiting the activity of natural killer (NK) cells and other immune cells that are important for tumor surveillance.
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2↓, GM-CSF↓, angioG↓, VEGF↓, CD31↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

CD31↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   GM-CSF↓, 2,   p‑IKKα↓, 1,   IL1↓, 1,   IL6↓, 1,   MDSCs↓, 1,   MyD88↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TLR4↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MDSCs, Myeloid-derived suppressor cells
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:672  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page