ER Stress Cancer Research Results

ER Stress, endoplasmic reticulum (ER) stress signaling pathway: Click to Expand ⟱

Source:

Type:

Protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.
The endoplasmic reticulum (ER) stress signaling pathway plays a crucial role in maintaining cellular homeostasis and responding to various stressors, including those encountered in cancer. When cells experience stress, such as the accumulation of misfolded proteins, they activate a series of signaling pathways collectively known as the unfolded protein response (UPR). The UPR aims to restore normal function by enhancing the protein-folding capacity of the ER, degrading misfolded proteins, and, if the stress is unresolved, triggering apoptosis.
The activation of ER stress pathways can contribute to resistance against chemotherapy and targeted therapies. Cancer cells may utilize the UPR to survive treatment-induced stress, making it challenging to achieve effective therapeutic outcomes.

-ER stress-associated proteins include: phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12

Liver, Liver Cancer: Click to Expand ⟱

Liver Cancer

Scientific Papers found: Click to Expand⟱

5146-

AgNPs,

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

in-vitro,

Liver,

HepG2

TumAuto↑, EPR↑, LC3B↑, CHOP/DDIT3↑, ER Stress↑, NLRP3↑, Casp1↓,

1361-

Ash,

SRF,

Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells

in-vitro,

Liver,

HUH7

in-vivo,

Liver,

HUH7

TrxR↓, ROS↑, DNA-PK↑, ER Stress↑, Apoptosis↑, eff↓,

2680-

BBR,

PDT,

Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death

in-vitro,

Liver,

HUH7

TumCD↑, ROS↑, TumCCA↑, ER Stress↑,

7439-

CYN,

Cynaropicrin Induces Reactive Oxygen Species-Dependent Paraptosis-Like Cell Death in Human Liver Cancer Cells

in-vitro,

Liver,

Hep3B

tumCV↓, mtDam↑, ER Stress↑, i-Ca+2↑, ROS↑, Alix/AIP‑1↓, eff↓,

2841-

FIS,

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer

in-vitro,

Nor,

RAW264.7

LPS-induced Raw264.7 cells

in-vitro,

Liver,

HepG2

10, 25, 100, and 200 μM, 24 h

in-vitro,

Liver,

Hep3B

in-vitro,

Liver,

HUH7

*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,

1960-

GamB,

Vem,

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation

in-vitro,

Liver,

HepG2

in-vitro,

AML,

K562

Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,

839-

Gra,

Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway

in-vitro,

Liver,

HepG2

tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP/DDIT3↑,

2863-

HNK,

Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells

in-vitro,

Liver,

Hep3B

ER Stress↑, Ca+2↑, mtDam↑, PTEN↑, PARK2↑, Alix/AIP‑1↓, ROS↑, mt-ROS↑,

7384-

MF,

Reactive oxygen species (ROS) production in HepG2 cancer cell line through the application of localized alternating magnetic field

in-vitro,

Liver,

HepG2

ROS↑, tumCV↓, mtDam↑, Dose↝, ER Stress↑,

3417-

TQ,

Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress

in-vitro,

BC,

MCF7

in-vitro,

Liver,

HepG2

TumCP↓, NF-kB↓, cl‑Casp3↑, GRP78/BiP↑, ER Stress↑, Apoptosis↑,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,
Total Targets: 43

Pathway results for Effect on Normal Cells:

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1, IL6↓, 1, Inflam↓, 1, TNF-α↓, 1,

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,
Total Targets: 5

Scientific Paper Hit Count for: ER Stress, endoplasmic reticulum (ER) stress signaling pathway

1 Silver-NanoParticles
1 Ashwagandha(Withaferin A)
1 Sorafenib (brand name Nexavar)
1 Berberine
1 Photodynamic Therapy
1 Cynaropicrin
1 Fisetin
1 Gambogic Acid
1 verapamil
1 Graviola
1 Honokiol
1 Magnetic Fields
1 Thymoquinone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:103  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

ER Stress Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Pathway results for Effect on Normal Cells:

Immune & Inflammatory Signaling(tgid=16) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

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