AEG1 Cancer Research Results

AEG1, Astrocyte Elevated Gene-1: Click to Expand ⟱
Source:
Type:
AEG-1 (Astrocyte Elevated Gene-1), also known as Metadherin (MTDH) or LYRIC, is an oncogene that has garnered considerable attention due to its multifaceted roles in tumor progression, metastasis, and chemoresistance.
AEG-1 is involved in several cellular processes including proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition (EMT).
It influences multiple signaling pathways such as PI3K/AKT, NF-κB, and Wnt/β-catenin, which are critical for promoting survival, proliferation, and metastatic potential.
AEG-1’s ability to interact with various proteins and pathways makes it a central hub in fostering a supportive environment for tumor growth and progression.

AEG-1 is overexpressed in a wide range of cancers including breast, prostate, liver (hepatocellular carcinoma), glioblastoma, melanoma, and colorectal cancers, among others.
High expression levels are frequently detected in advanced tumor stages and often correlate with aggressive tumor phenotypes.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
1139- UA,    Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells
- in-vitro, Lung, A549
TumMeta↓, AEG1↓, E-cadherin↑, N-cadherin↓, Vim↓, EMT↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

AEG1↓, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   TumMeta↓, 1,   Vim↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AEG1, Astrocyte Elevated Gene-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1015  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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