12LOX Cancer Research Results

12LOX, 12‐lipoxygenase: Click to Expand ⟱
Source:
Type:
12‐lipoxygenase (commonly abbreviated as 12-LOX)
12-LOX (12-lipoxygenase) is an enzyme that plays a role in the metabolism of polyunsaturated fatty acids—in particular, converting arachidonic acid into bioactive lipid mediators such as 12-hydroxyeicosatetraenoic acid (12-HETE).
-12-LOX is implicated in several mechanisms that can promote cancer, including supporting inflammation, cell survival, angiogenesis, and metastasis.
High 12-LOX expression in several cancer types is generally correlated with more aggressive disease and poorer clinical outcomes. However, the prognostic significance may vary between cancers and patient populations. Ongoing research is aiming to clarify:
– Whether 12-LOX can be reliably used as a prognostic biomarker
– And whether targeting 12-LOX might serve as a therapeutic strategy in cancer management.
– Increased Levels of 12-LOX in ESCC Patients with Poor Prognosis
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
5498- Ba,    Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis
- in-vitro, Lung, H460
12LOX↓, Dose↝, TumCCA↑, CDK1↓, CycB/CCNB1↓, Apoptosis↑, Bcl-2↓, P53↑, BAX↑, TumCP↓,
5499- Ba,    Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, F-actin↓, TumVol↓, OS↑, 12LOX↓, VEGF↓, angioG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

12LOX↓, 2,  

Cell Death ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Migration ⓘ

F-actin↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 12LOX, 12‐lipoxygenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1126  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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