HDAC6 Cancer Research Results

HDAC6, HDAC6: Click to Expand ⟱
Source:
Type:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that plays a significant role in regulating various cellular processes, and its dysregulation has been implicated in cancer pathogenesis and progression.
-HDAC6 primarily deacetylates non-histone proteins, including α-tubulin and heat shock protein 90 (Hsp90).
-Many studies have reported overexpression or hyperactivation of HDAC6 in different cancer types.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Protein Folding & ER Stress ⓘ

HSP90↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

HDAC6↓, 2,  

Migration ⓘ

MMP9↓, 2,   TumCI↓, 2,   TumCMig↓, 2,   α-tubulin↑, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC6, HDAC6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1335  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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