NPL4 Cancer Research Results

NPL4, NPLOC4: Click to Expand ⟱
Source:
Type:

NPL4 is not an enzyme itself. It is a ubiquitin-recognition adaptor that works with UFD1 and VCP/p97 to extract ubiquitinated proteins from membranes, chromatin and protein complexes for processing or proteasomal degradation. It is involved in ER-associated degradation, DNA replication, DNA repair and mitotic functions.

In cancer, NPL4/NPLOC4 is generally considered tumour-promoting when increased or active.

Disulfiram modulates NPL4 in the inhibitory direction:

Disulfiram + copper → NPL4 aggregation/immobilization → NPL4 function ↓

More precisely, disulfiram is converted to diethyldithiocarbamate, which complexes with copper to form CuET [Cu(DDC)₂]. 
CuET binds to NPL4 and causes it to cluster into insoluble aggregates. 
This disables NPL4 as an adaptor of the VCP/p97–UFD1–NPL4 segregase complex


Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
6741- DSF,    Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET
- vitro+vivo, Lung, A549
NPL4↓, P53↑,
6739- DSF,    Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
- in-vitro, Lung, H1299 - in-vitro, Lung, A549
ALDH↓, eff↝, NPL4↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NPL4↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NPL4, NPLOC4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1526  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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