miR-106b Cancer Research Results

miR-106b, MicroRNA-106b: Click to Expand ⟱
Source:
Type:

miR-106b - MicroRNA-106b

Abbreviation: miR-106b, miR-106b-5p

Type: MicroRNA / miR-106b~25 cluster member

Function: Regulatory microRNA involved in cell-cycle progression, proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition, and treatment resistance through post-transcriptional suppression of multiple target genes and tumor-suppressive pathways.

Cancer: ↑ Frequently increased and oncogenic in multiple cancers. Elevated miR-106b can promote proliferation, migration, invasion, EMT, metastasis, and resistance to therapy through suppression of tumor-suppressor genes and regulatory pathways.

Alzheimer's Disease: ↓ Reduced miR-106b-5p has been reported in peripheral blood from Alzheimer's disease patients and has been investigated as a potential circulating biomarker.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7323- GSE,    Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity
- vitro+vivo, Lung, NA
miR-106b↓, P21↑, TumCG↓, Dose↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF-2R↑, 1,   miR-106b↓, 2,   PGI2↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   miR-19b↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   toxicity↝, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-106b, MicroRNA-106b
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1626  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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