JAK2 Cancer Research Results

JAK2, Janus kinase 2: Click to Expand ⟱

Source: CGL-Driver Genes

Type: Oncogene

A tyrosine kinase that plays a crucial role in the signaling pathways of various cytokines and growth factors. It is particularly important in hematopoiesis (the formation of blood cells) and immune responses.

JAK2 plays a significant role in cancer biology, particularly in hematological malignancies, where its expression and activity are often upregulated. Increased JAK2 activity is generally associated with worse prognosis in many cancers, indicating its potential role in promoting tumor growth and survival.

Lung, Lung Cancer: Click to Expand ⟱

Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)

Scientific Papers found: Click to Expand⟱

6186-

Cuc,

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

vitro+vivo,

Lung,

A549

in-vitro,

BC,

MDA-MB-453

STAT3↓, JAK2↓, TumCG↓,

4676-

CUR,

Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway

vitro+vivo,

Lung,

H460

CSCs↓, JAK2↓, STAT3↓, TumCP↓, TumCG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, STAT3↓, 2, TumCG↓, 2,

Migration ⓘ

TumCP↓, 1,

Immune & Inflammatory Signaling ⓘ

JAK2↓, 2,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: JAK2, Janus kinase 2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells