p38 Cancer Research Results

p38, p38: Click to Expand ⟱

Source:

Type:

P38, or p38 MAPK (p38 mitogen-activated protein kinase), is a protein kinase that plays a significant role in cellular responses to stress, inflammation, and apoptosis (programmed cell death). It is part of the MAPK signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and survival.
It can have both tumor-suppressive and tumor-promoting effects, depending on the type of cancer and the cellular context.

-p38 activation can contribute to tumor progression by influencing inflammatory signaling and cell-cycle regulation.
-Overexpression can correlate with poor prognosis in some studies.

Lung, Lung Cancer: Click to Expand ⟱

Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)

Scientific Papers found: Click to Expand⟱

1150-

Api,

Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement

in-vitro,

Lung,

EAhy926

50 μM

eNOS↓, MMP9↓, Akt↓, p38↓, JNK↓,

1209-

SANG,

Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration

in-vitro,

Lung,

A549

VEGF↓, TumCMig↓, Akt↓, p38↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Akt↓, 2, JNK↓, 1, p38↓, 2,

Migration ⓘ

MMP9↓, 1, TumCMig↓, 1,

Angiogenesis & Vasculature ⓘ

eNOS↓, 1, VEGF↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: p38, p38

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells