Wnt/(β-catenin) Cancer Research Results

Wnt/(β-catenin), Wnt/(β-catenin): Click to Expand ⟱
Source: HalifaxProj (inhibit) TCGA
Type:
The Wnt signaling pathway is activated when Wnt proteins bind to Frizzled receptors on the cell surface, leading to the stabilization and accumulation of β-catenin in the cytoplasm and its subsequent translocation to the nucleus.
In the nucleus, β-catenin interacts with transcription factors to activate target genes that promote cell growth and survival.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
10- CUR,    Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
HH↓, Wnt/(β-catenin)↓, Shh↓, Smo↓, Gli1↝, GLI2↝, CSCs↓, CD133↓, CSCsMark↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   CSCsMark↓, 1,   Gli1↝, 1,   HH↓, 1,   Shh↓, 1,   Smo↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

GLI2↝, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Wnt/(β-catenin), Wnt/(β-catenin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:338  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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