Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
1030- BBR,    Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5
- in-vitro, Lung, H460
PD-L1↓, TumCG↓, Ki-67↓, cl‑Casp3↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
686- EGCG,    Prevention effect of EGCG in rat's lung cancer induced by benzopyrene
- in-vivo, Lung, NA
NF-kB↓, p50↓, Ki-67↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7326- GSE,    LEUCOSELECT PHYTOSOME MODULATES SERUM EICOSAPENTAENOIC ACID, DOCOSAHEXAENOIC ACID and PROSTAGLANDIN E3 IN A PHASE 1 LUNG CANCER CHEMOPREVENTION STUDY
- in-vitro, Lung, A549 - in-vitro, Lung, H520
antiNeop↑, Ki-67↓, other↑, PGE3↑,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF-2R↑, 1,   miR-106b↓, 1,   PGE3↑, 1,   PGI2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 1,   GPx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FABP4↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PPARα↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   Mcl-1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 1,   Gli1↓, 1,   GSK‐3β↑, 1,   IGFBP3↓, 1,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ki-67↓, 8,   miR-19b↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   p50↓, 1,   PD-L1↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 2,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   Ki-67↓, 8,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoPv↑, 2,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
2 Grapeseed extract
1 Berberine
1 Beta-Caryophyllene
1 EGCG (Epigallocatechin Gallate)
1 Formononetin
1 Resveratrol
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:425  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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