ABC Cancer Research Results

ABC, ABC transporter: Click to Expand ⟱
Source:
Type:
ABC (ATP-binding cassette) transporters are a family of proteins that play a crucial role in the transport of various molecules across cell membranes.
ABC transporters have been implicated in the development of multidrug resistance, which is a major obstacle in cancer treatment.
Overexpression of certain ABC transporters, such as P-glycoprotein (P-gp), has been observed in various types of cancer, including breast, lung, and colon cancer.
Examples of ABC transporters implicated in cancer include:
- P-glycoprotein (P-gp, ABCB1)
- Multidrug resistance-associated protein 1 (MRP1, ABCC1)
- Breast cancer resistance protein (BCRP, ABCG2)
Prognostic Implications
-Drug Resistance: High expression of ABC transporters is often linked to resistance against chemotherapy, leading to treatment failure and poor patient outcomes.
-Survival Rates: Patients with tumors expressing high levels of certain ABC transporters may have lower overall survival rates.
Target for Therapy: Inhibitors of ABC transporters are being explored as potential adjuncts to improve the efficacy of chemotherapy.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
4956- PEITC,    Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells
- vitro+vivo, Lung, A549
GSH↓, ROS↑, mtDam↑, mitResp↓, MMP↓, CSCs↓, OCT4↓, ABC↓, SOX2↓, CD133↓, CD44↓, ALDH↓, Nanog↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↓, 1,   mtDam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   Nanog↓, 1,   OCT4↓, 1,   SOX2↓, 1,   TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABC, ABC transporter
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:621  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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