cycA1/CCNA1 Cancer Research Results

cycA1/CCNA1, cyclin A1: Click to Expand ⟱
Source:
Type:
Cyclin A1 is a protein that plays a crucial role in the regulation of the cell cycle, which is the process by which cells grow and divide. It is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer, and its overexpression has been linked to poor prognosis and reduced survival rates.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
5593- BetA,    Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth
- in-vitro, Lung, NA
Sp1/3/4↓, cycA1/CCNA1↓, p‑RB1↓, TumCCA↑,
6858- FBZ,    Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells
- in-vitro, Lung, A549
eff↑, mt-ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, PARP↑, TumCCA↑, cycA1/CCNA1↓, cycE/CCNE↓,
3415- TQ,    The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations
- in-vitro, Lung, H446
tumCV↓, TumCCA↑, ROS↓, CycB/CCNB1↑, CycD3↑, cycA1/CCNA1↓, cycE/CCNE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE/EpRE↑, 1,   NRF2↓, 1,   ROS↓, 1,   mt-ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycA1/CCNA1↓, 3,   CycB/CCNB1↑, 1,   CycD3↑, 1,   cycE/CCNE↓, 2,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cycA1/CCNA1, cyclin A1
1 Betulinic acid
1 Fenbendazole
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:653  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page