MDSCs Cancer Research Results

MDSCs, Myeloid-derived suppressor cells: Click to Expand ⟱
Source:
Type:
Myeloid-derived suppressor cells (MDSCs) are a type of immune cell that plays a significant role in cancer progression and immune evasion. They are a heterogeneous group of cells that are characterized by their ability to suppress the immune response, particularly the activity of T cells.

MDSCs are typically found in the tumor microenvironment and are thought to be recruited to the tumor site by various factors, including tumor-derived cytokines and chemokines. Once at the tumor site, MDSCs can suppress the immune response in several ways, including:
-Inhibiting the activation and proliferation of T cells.
-Suppressing the production of cytokines and chemokines that are necessary for an effective immune response.
-Inducing the production of anti-inflammatory cytokines that promote tumor growth and survival.
-Inhibiting the activity of natural killer (NK) cells and other immune cells that are important for tumor surveillance.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
MDSCs↓, TregCell↓, IL10↓, NK cell↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

TregCell↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 1,   MDSCs↓, 1,   NK cell↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MDSCs, Myeloid-derived suppressor cells
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:672  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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