LOX1 Cancer Research Results

LOX1, Lectin-like oxidized low-density lipoprotein receptor 1: Click to Expand ⟱
Source:
Type:
LOX-1 (Lectin-like oxidized low-density lipoprotein receptor 1) is a protein that has been implicated in various diseases, including cancer. Research has shown that LOX-1 is overexpressed in several types of cancer, including breast, lung, colon, and prostate cancer.

LOX-1 is involved in the regulation of cell proliferation, apoptosis (cell death), and angiogenesis (the formation of new blood vessels). In cancer, LOX-1 can promote tumor growth and metastasis by:

Enhancing cell proliferation and survival
Inhibiting apoptosis
Promoting angiogenesis
Facilitating the migration and invasion of cancer cells
Studies have also shown that LOX-1 can interact with other molecules involved in cancer progression, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

Inhibiting LOX-1 has been proposed as a potential therapeutic strategy for cancer treatment.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
432- CUR,    Curcumin-Induced Global Profiling of Transcriptomes in Small Cell Lung Cancer Cells
- in-vitro, Lung, H446
Bcl-2↓, cycF↓, LOX1↓, VEGF↓, MRGPRF↓, BAX↑, Cyt‑c↑, miR-548ah-5p↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Cyt‑c↑, 1,   miR-548ah-5p↑, 1,  

Cell Cycle & Senescence ⓘ

cycF↓, 1,  

Migration ⓘ

MRGPRF↓, 1,  

Angiogenesis & Vasculature ⓘ

LOX1↓, 1,   VEGF↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LOX1, Lectin-like oxidized low-density lipoprotein receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:680  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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