eNOS Cancer Research Results

eNOS, endothelial Nitric Oxide Synthase: Click to Expand ⟱

Source:

Type:

Endothelial Nitric Oxide Synthase is an enzyme that is constitutively expressed in endothelial cells, which line the blood vessels.
-Vascular Signaling, Angiogenesis, and Context-Dependent Effects
-It generates nitric oxide (NO) from L-arginine in a calcium/calmodulin- and phosphorylation-dependent manner.

eNOS is a vascular and microenvironmental regulator that usually supports cancer by enabling angiogenesis, perfusion, and survival signaling. Its effects are highly context-dependent—beneficial for normal tissue homeostasis, but often co-opted by tumors to sustain growth and resist therapy. Therapeutic strategies typically modulate upstream pathways rather than directly targeting eNOS itself.

Lung, Lung Cancer: Click to Expand ⟱

Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)

Scientific Papers found: Click to Expand⟱

1150-

Api,

Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement

in-vitro,

Lung,

EAhy926

50 μM

eNOS↓, MMP9↓, Akt↓, p38↓, JNK↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Akt↓, 1, JNK↓, 1, p38↓, 1,

Migration ⓘ

MMP9↓, 1,

Angiogenesis & Vasculature ⓘ

eNOS↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: eNOS, endothelial Nitric Oxide Synthase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells