SHP1 Cancer Research Results

SHP1, Src Homology region 2 domain-containing Phosphatase-1: Click to Expand ⟱
Source:
Type:
SHP1 is a non-receptor protein tyrosine phosphatase primarily encoded by the gene PTPN6.
Immune Checkpoint Brake, Tumor Suppressor Signaling, and Immune Evasion

– In blood cancers such as leukemia and lymphoma, altered SHP1 expression (often downregulation) is frequently observed.
– Downregulation or loss of SHP1 is often associated with more aggressive disease phenotypes and poorer prognosis.
Direction of Regulation in Cancer 
Two distinct, context-specific directions:
A. Tumor Cells (especially hematologic malignancies): DOWNREGULATED
-Frequently silenced epigenetically (promoter methylation)
-Rarely mutated; loss is regulatory
-Results in unchecked growth and survival signaling

B. Immune Cells within the Tumor Microenvironment: FUNCTIONALLY UPREGULATED
-Actively recruited by inhibitory receptors
-Suppresses T-cell, NK-cell, and myeloid anti-tumor responses
-Promotes immune evasion

This duality is critical to interpret SHP1 correctly.

When SHP1 is lost in tumor cells:
-JAK–STAT signaling becomes hyperactive
-Growth and survival pathways escape negative feedback
-Cells gain a proliferative and survival advantage


Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
7244- Gink,    Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases
- in-vitro, Lung, A549 - in-vitro, Laryn, FaDu
p‑STAT3↓, JAK1↓, Src↓, SHP1↑, PTEN↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 1,   SHP1↑, 1,   Src↓, 1,   p‑STAT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK1↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SHP1, Src Homology region 2 domain-containing Phosphatase-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1331  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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