IGF-2R Cancer Research Results

IGF-2R, Insulin-Like Growth Factor 2 Receptor: Click to Expand ⟱
Source:
Type:

IGF-2R - Insulin-Like Growth Factor 2 Receptor

Abbreviation: IGF-2R, IGF2R, CI-M6PR, M6P/IGF2R

Type: Growth-factor scavenger receptor / cation-independent mannose-6-phosphate receptor

Function: Cell-surface and intracellular trafficking receptor that binds insulin-like growth factor 2 (IGF-2) and mannose-6-phosphate-containing proteins. IGF2R internalizes and directs IGF-2 toward lysosomal degradation, thereby limiting IGF-2-mediated mitogenic signaling. It also regulates lysosomal enzyme trafficking and contributes to activation of TGF-β.

Cancer: ↓ Frequently reduced, mutated, or lost in cancer and generally functions as a tumor suppressor. Loss of IGF2R can increase extracellular IGF-2 availability and enhance proliferative IGF signaling. Loss of heterozygosity and inactivating alterations of IGF2R have been reported in multiple malignancies and can be associated with tumor progression and poorer outcome.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7322- GSE,    MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
miR-19b↓, IGF-2R↑, PTEN↑, p‑Akt↓, Dose↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF-2R↑, 2,   miR-106b↓, 1,   PGI2↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 2,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 2,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   miR-19b↓, 2,   TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   toxicity↝, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGF-2R, Insulin-Like Growth Factor 2 Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1625  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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