PTEN Cancer Research Results

PTEN, phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
PTEN (Phosphatase and Tensin Homolog) is a crucial tumor suppressor gene that plays a significant role in regulating cell growth, proliferation, and survival. It encodes a protein that functions as a phosphatase, which means it removes phosphate groups from specific molecules, thereby regulating various signaling pathways, particularly the PI3K/AKT pathway.
PTEN is mutated, deleted, or otherwise inactivated. This loss of function can lead to increased cell proliferation and survival, contributing to tumorigenesis. PTEN mutations are commonly found in various cancers, including:
Prostate cancer
Breast cancer
Endometrial cancer
Glioblastoma
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
430- CUR,    Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling
- vitro+vivo, Lung, A549
PTEN↑, MEG3↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
7244- Gink,    Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases
- in-vitro, Lung, A549 - in-vitro, Laryn, FaDu
p‑STAT3↓, JAK1↓, Src↓, SHP1↑, PTEN↑,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7322- GSE,    MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
miR-19b↓, IGF-2R↑, PTEN↑, p‑Akt↓, Dose↝,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF-2R↑, 2,   miR-106b↓, 1,   PGI2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR∅, 1,   Glycolysis↓, 1,   PDK1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 3,   Apoptosis↑, 1,   Casp↑, 1,   MEG3↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   p‑eIF2α↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1R↓, 1,   p‑IGF-1R↓, 1,   mTOR⇅, 1,   PTEN↑, 7,   SHP1↑, 1,   Src↓, 1,   p‑STAT3↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   miR-19b↓, 2,   TSC1↑, 1,   TumCP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL1↑, 1,   IL10↑, 1,   Inflam↓, 1,   JAK1↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,   Dose∅, 2,   eff↑, 2,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   toxicity↝, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,  
Total Targets: 5

Scientific Paper Hit Count for: PTEN, phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
2 Grapeseed extract
1 Citric Acid
1 Curcumin
1 Ellagic acid
1 Ginkgetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:267  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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