TIMP1 Cancer Research Results

TIMP1, Tissue Inhibitor of Metalloproteinases-1: Click to Expand ⟱

Source:

Type:

A protein that plays a role in the regulation of matrix metalloproteinases (MMPs), which are enzymes involved in the breakdown of the extracellular matrix.
TIMP-1 is overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer. High levels of TIMP-1 have been associated with poor prognosis and increased risk of metastasis (cancer spread) in some cancers.

Lung, Lung Cancer: Click to Expand ⟱

Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)

Scientific Papers found: Click to Expand⟱

247-

AL,

Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1299

MMP2↓, MMP9↓, TIMP1↑, TIMP2↑, p‑Akt↓, PI3K/Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 1,

Cell Death ⓘ

p‑Akt↓, 1,

Migration ⓘ

MMP2↓, 1, MMP9↓, 1, TIMP1↑, 1, TIMP2↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TIMP1, Tissue Inhibitor of Metalloproteinases-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells