eff Cancer Research Results

eff, efficacy: Click to Expand ⟱

Source:

Type:

Power to enhance an anti cancer effect

Lung, Lung Cancer: Click to Expand ⟱

Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)

Scientific Papers found: Click to Expand⟱

5467-

AF,

Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth

in-vitro,

Lung,

DMS53 human small cell lung cancer cells

TrxR↓, eff↑, Dose↝, OS↑, eff↑,

5441-

AG,

Chemo,

Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients

Review,

Lung,

 65 RCTs enrolling 4751 patients.

eff↑, ChemoSen↑,

4376-

AgNPs,

Interaction of multi-functional silver nanoparticles with living cells

in-vitro,

Nor,

L929

in-vitro,

Lung,

A549

eff↑, selectivity↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,

4551-

AgNPs,

FBZ,

Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy

in-vivo,

Lung,

mice

eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,

7426-

AgNPs,

CS,

Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

in-vitro,

Pca,

PC3

0.85 μg/mL

in-vitro,

Lung,

A549

 0.94 μg/mL

*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

2575-

ART/DHA,

docx,

Artemisia santolinifolia-Mediated Chemosensitization via Activation of Distinct Cell Death Modes and Suppression of STAT3/Survivin-Signaling Pathways in NSCLC

in-vitro,

Lung,

H23

AS at concentrations of 100 and 200 μg/mL in combination with DTX at concentrations of 0.5, 1 and 2.5 nM for 48 h.

ChemoSen↑, GPx4↓, ROS↑, Ferroptosis↑, eff↑,

1360-

Ash,

immuno,

Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer

in-vitro,

Lung,

H1650

in-vitro,

Lung,

A549

in-vitro,

CRC,

HCT116

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

mice

PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP/DDIT3↑, p‑eIF2α↑, ICD↑, eff↑,

1525-

Ba,

almon,

Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway

in-vitro,

Lung,

H1975

in-vivo,

Lung,

mice

eff↑, TumCP↓, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp9↑, p‑PI3K↓, p‑Akt↓, ROS↑, eff↓,

5543-

BBM,

Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo

in-vivo,

Lung,

B16-F10

C57BL/6 mice

vitro+vivo,

Lung,

A549

in-vitro,

BC,

MDA-MB-231

BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,

2702-

BBR,

The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1975

TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1↓, DNMT1↓, eff↑,

6497-

BCP,

Cisplatin,

Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules

in-vitro,

Lung,

TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,

2755-

BetA,

Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines

in-vitro,

Colon,

HT29

in-vitro,

BC,

MCF7

in-vitro,

Lung,

H460

eff↑, Casp3↑, Casp7↑, NF-kB↓,

5844-

CAP,

Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers

in-vitro,

Lung,

DMS114

eff↑, AMPK↑, toxicity↝, BioAv↑, TRPV1↑, TumCI↓,

5880-

CAR,

In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis

vitro+vivo,

Lung,

A549

nude mice, present study commenced to formulate CANE by an energy intensive ultrasonication method.

in-vitro,

Nor,

BEAS-2B

in-vitro,

Lung,

PC9

Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,

7160-

CHA,

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

in-vitro,

Lung,

A549

selectivity↑, eff↑, ROS↑, Apoptosis↓, HDAC↓, MMP↓, cl‑PARP↑, eff↑, eff↓, i-GSH∅,

5997-

Chit,

Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU

in-vivo,

Lung,

mice

Imm↑, TumMeta↓, eff↑,

6131-

CHr,

Bor,

Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells

in-vitro,

Lung,

A549

*BioAv↑, ROS↑, TumCD↑, TumCCA↑, MMP2↓, TumMeta↓, TumCI↓, GSH↓, eff↑,

1574-

Citrate,

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

in-vitro,

Lung,

A549

5,10,15mM

in-vitro,

Melanoma,

WM983B

in-vivo,

NA,

4 g/kg citrate twice a day for 4 week

mice. Plasma levels in chronically treated animals were approximately 3 mM

TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,

6292-

Cro,

Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms

in-vitro,

Cerv,

HeLa

 crocetin (60-240 μmol/L) for 48 h

in-vitro,

Lung,

A549

in-vitro,

Ovarian,

SKOV3

TumCP↓, TumCCA↑, P21↑, Apoptosis↑, eff↑,

1602-

Cu,

A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†

in-vitro,

BC,

MCF7

3.2uM

in-vitro,

BC,

4T1

3.3uM

in-vitro,

Lung,

A549

4uM

in-vitro,

Liver,

HepG2

3.5uM

eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,

1981-

CUR,

Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity

in-vitro,

Lung,

eff↑, ROS↑, mt-GSH↓, Bax:Bcl2↑, Cyt‑c↑, MMP↓, Casp3↑, Trx2↓, TrxR↓, mt-DNAdam↑,

1979-

CUR,

Rad,

Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase

in-vitro,

Lung,

A549

eff↑, ROS↑, GSH/GSSG↓, TrxR↓, selectivity↑,

1977-

CUR,

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors

in-vitro,

BC,

MCF7

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

TrxR↓, Dose↝, eff↑,

1876-

DCA,

Chemo,

In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines

in-vivo,

Lung,

H727

eff↑, TumCG↓, Glycolysis↓, mitResp↑,

6671-

Deg,

A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy

in-vitro,

Nor,

BEAS-2B

in-vitro,

Lung,

H1299

in-vitro,

Lung,

H460

HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,

1608-

EA,

Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity

in-vitro,

Cerv,

HeLa

35 μg/mL

in-vitro,

Liver,

HepG2

220ug/mL

in-vitro,

BC,

MCF7

75 ug/mL

in-vitro,

Lung,

A549

242um/mL

in-vitro,

Nor,

HUVECs

258um/mL

eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,

3212-

EGCG,

EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells

in-vitro,

Lung,

A549

in-vivo,

Lung,

NCIH23

NRF2⇅, eff↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,

6853-

FBZ,

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways

vitro+vivo,

Lung,

A549

in-vitro,

Lung,

H460

TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, eff↑, Dose↝, TumCG↓,

6858-

FBZ,

Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells

in-vitro,

Lung,

A549

eff↑, mt-ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, PARP↑, TumCCA↑, cycA1/CCNA1↓, cycE/CCNE↓,

6859-

FBZ,

DCA,

Synergistic anti-tumor effect of fenbendazole and diisopropylamine dichloroacetate in immunodeficient BALB/c nude mice transplanted with A549 lung cancer cells

in-vivo,

Lung,

A549

mice

Remission↑, eff↑,

7043-

GA,

Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase

in-vitro,

Lung,

Calu-1

in-vitro,

Lung,

A549

TumCG↓, MMP↓, ROS↑, GSH↓, eff↑, eff↓, eff↑, mtDam↑, Ca+2↑,

1966-

GamB,

Cisplatin,

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

in-vitro,

Lung,

A549

in-vitro,

Lung,

NCIH1299

TumCCA↑, PARP↑, eff↑, ROS↑, ChemoSen↑,

7286-

GGB,

Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

in-vitro,

Lung,

A549

in-vitro,

Lung,

PC9

Hif1a↓, Glycolysis↓, OXPHOS↑, ROS↑, Apoptosis↑, toxicity↓, PDKs↓, HK2↓, LDHA↓, PFKFB2↓, PKM2↓, eff↑,

7138-

GI,

6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways

vitro+vivo,

BC,

MDA-MB-231

in-vitro,

Pca,

DU145

in-vitro,

Liver,

HepG2

in-vitro,

Lung,

A549

TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2↓, IAP1↓, Dose?,

1904-

GoldNP,

AgNPs,

Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis

in-vitro,

Lung,

H157

in-vitro,

BC,

MCF7

in-vitro,

Colon,

HCT15

in-vitro,

Melanoma,

A375

TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,

7313-

Gos,

Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

in-vitro,

Lung,

H460

selectivity↑, eff↑,

7454-

HNK,

Updated progression of honokiol in lung cancer treatment

Review,

Lung,

AntiCan↑, eff↑,

2886-

HNK,

Liposomal honokiol inhibits non-small cell lung cancer progression and enhances PD-1 blockade via suppressing M2 macrophages polarization

in-vitro,

Lung,

A549

in-vitro,

Lung,

H460

in-vivo,

NA,

 mouse Lewis lung cancer cell line (LL2

eff↑, BioAv↑, eff↑, PI3K↓, Akt↓,

2895-

HNK,

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

in-vitro,

Lung,

PC9

 0.26 μM

eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,

1041-

Lyco,

immuno,

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells

in-vivo,

Lung,

mice

TumVol↓, TumW↓, eff↑, IL1↑, IFN-γ↑, IL4↓, IL10↓,

1712-

Lyco,

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

in-vitro,

Lung,

A549

ROS↓, ROS↑, eff↑,

1997-

Myr,

QC,

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity

in-vitro,

Lung,

A549

50, 75, and 100 umol/L

<1uM

TrxR↓, eff↑, TumCCA↑, eff↓, ROS↑,

2074-

PB,

Chemo,

The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells

in-vitro,

Lung,

A549

10uM

in-vitro,

Lung,

Calu-6

8.53uM

in-vitro,

Lung,

H1650

4.53uM

TumCG↓, eff↑, ChemoSen↑, HDAC↓,

1769-

PG,

The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels

in-vitro,

Lung,

Calu-6

in-vitro,

Lung,

A549

TumCP↓, eff↑, ROS↑, GSH↓,

1770-

PG,

Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation

in-vitro,

Lung,

antiOx↑, Inflam↓, HO-1↓, eff↑, ChemoSen↑,

1765-

PG,

Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion

in-vitro,

Lung,

A549

800 uM at 24 h

in-vitro,

Lung,

Calu-6

TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,

1951-

PL,

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

in-vitro,

Lung,

A549

ROS↑, lipid-P↑, MMP↓, TumCCA↑, TrxR↓, eff↑,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

in-vitro,

CRC,

HCT116

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF7

TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,

Showing Research Papers: 1 to 50 of 56
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 56

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 3, BioEnh↑, 1, Half-Life∅, 1,

Functional Outcomes(tgid=23) ⓘ

toxicity?, 1, toxicity∅, 2,
Total Targets: 7

Scientific Paper Hit Count for: eff, efficacy

5 Silver-NanoParticles
4 Fenbendazole
3 Chemotherapy
3 Curcumin
3 Honokiol
3 Propyl gallate
2 immunotherapy
2 Berberine
2 Cisplatin
2 Dichloroacetate
2 Lycopene
2 Quercetin
2 Piperlongumine
1 Auranofin
1 Astragalus
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Docetaxel
1 Ashwagandha(Withaferin A)
1 Baicalein
1 almonertinib
1 Berbamine
1 Beta-Caryophyllene
1 Betulinic acid
1 Capsaicin
1 Carvacrol
1 chaetocin
1 chitosan
1 Chrysin
1 Boron
1 Zinc
1 Citric Acid
1 Crocetin
1 Copper and Cu NanoParticles
1 Radiotherapy/Radiation
1 Deguelin
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Gallic acid
1 Gambogic Acid
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Gold NanoParticles
1 Gossypol/AT-101
1 Myricetin
1 Phenylbutyrate
1 Resveratrol
1 SonoDynamic Therapy UltraSound
1 Shikonin
1 Thymoquinone
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

eff Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Functional Outcomes(tgid=23) ⓘ

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