Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5467- AF,    Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth
- in-vitro, Lung, NA
TrxR↓, eff↑, Dose↝, OS↑, eff↑,
7426- AgNPs,  CS,    Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation
- in-vitro, Pca, PC3 - in-vitro, Lung, A549
*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
5498- Ba,    Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis
- in-vitro, Lung, H460
12LOX↓, Dose↝, TumCCA↑, CDK1↓, CycB/CCNB1↓, Apoptosis↑, Bcl-2↓, P53↑, BAX↑, TumCP↓,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,
1977- CUR,    Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
TrxR↓, Dose↝, eff↑,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
6790- EPA,    Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia
- Trial, Lung, NA
*Dose↝, Weight↑, cachexia↓, OS∅,
6577- EU,    Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28
- in-vitro, Lung, A549
Dose↝, TumCP↓, PHB↓, ANXA1↓, p38↓,
6578- EU,    Eurycomanol and eurycomanone as potent inducers for cell-cycle arrest and apoptosis in small and large human lung cancer cell lines
- in-vitro, Lung, H460 - in-vitro, Lung, A549
Dose↝, selectivity↑, tumCV↓, TumCCA↓, Apoptosis↑,
6853- FBZ,    Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCD↑, P53↑, GlucoseCon↓, GLUT4↓, HK2↓, TumCG↓, P-gp∅, TumCCA↑, CycB/CCNB1↓, eff↑, selectivity↑, MMP↓, lactateProd↓, eff↑, Dose↝, TumCG↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
7317- Gos,    A phase II study of AT-101 (gossypol) in chemotherapy-sensitive recurrent extensive stage small cell lung cancer (ES-SCLC)
- Trial, Lung, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, NOXA↑, PUMA↑, Dose↝, eff↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7323- GSE,    Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity
- vitro+vivo, Lung, NA
miR-106b↓, P21↑, TumCG↓, Dose↝,
7322- GSE,    MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
miR-19b↓, IGF-2R↑, PTEN↑, p‑Akt↓, Dose↝,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
7523- HCA,    Inhibition of ATP Citrate Lyase by Hydroxycitrate-Loaded Exosomes Suppresses the Survival of Lung Adenocarcinoma Cells
- in-vitro, Lung, NA
ACLY↓, BioAv↓, Dose↝, TumCP↓, FASN↓, IDH1↓, Apoptosis↑, ROS↑, Half-Life↝,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,   IGF-2R↑, 2,   miR-106b↓, 2,   PGI2↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CoQ10↑, 1,   Ferroptosis↑, 1,   lipid-P↑, 1,   ROS↑, 3,   mt-ROS↑, 1,   Trx↓, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 4,   mtDam↑, 1,   PGC-1α↑, 1,   PHB↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ACC↑, 1,   ACLY↓, 1,   AMPK↑, 1,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   IDH1↓, 1,   lactateProd↓, 2,   LDH↑, 1,   PKM2↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 2,   Apoptosis↑, 9,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   p‑JNK↑, 1,   Mcl-1↓, 2,   NOXA↑, 1,   p38↓, 1,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   IRE1↑, 1,   XBP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 2,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   EMT↓, 1,   EP2↓, 1,   ERK↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   mTOR↓, 2,   PI3K↓, 1,   PTEN↑, 2,   STAT3↓, 1,   TumCG↓, 9,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CEA↓, 1,   Ki-67↓, 2,   miR-19b↓, 2,   N-cadherin↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCP↓, 7,   TumCP⇅, 1,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,   Hif1a↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 1,   P-gp∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   COX2↓, 2,   HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PDT+↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 24,   eff↓, 3,   eff↑, 8,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

CA125↓, 1,   CEA↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 1,   IL6↓, 1,   Ki-67↓, 2,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoPv↑, 2,   OS↑, 3,   OS∅, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 133

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,  
Total Targets: 3

Scientific Paper Hit Count for: Dose, Dosage
3 Grapeseed extract
2 Auranofin
2 Curcumin
2 Eurycomanone
2 Hydrogen Gas
1 Silver-NanoParticles
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Baicalein
1 Carvacrol
1 chaetocin
1 eicosapentaenoic acid
1 Fenbendazole
1 Formononetin
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Gossypol/AT-101
1 HydroxyCitric Acid
1 nicotinamide adenine dinucleotide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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