Cancer Database Query Results

Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
2432- 2DG,    Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
- in-vitro, Lung, H23 - in-vitro, Lung, KP2 - in-vivo, NA, NA
HK2↓, Apoptosis↑, TumAuto↑, TumCG↓,
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
7979- AAS/EEAA,    Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo
- vitro+vivo, Nor, HUVECs - in-vitro, Lung, H460
*angioG↓, VEGF↓, Hif1a↓,
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5467- AF,    Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth
- in-vitro, Lung, NA
TrxR↓, eff↑, Dose↝, OS↑, eff↑,
5441- AG,  Chemo,    Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients
- Review, Lung, NA
eff↑, ChemoSen↑,
1908- AgNPs,    Exposure to Silver Nanoparticles Inhibits Selenoprotein Synthesis and the Activity of Thioredoxin Reductase
- in-vitro, Lung, A549
TrxR↓, TrxR1↓, ROS↑, ER Stress↑, TumCP↓, selenoP↓,
1907- AgNPs,  GoldNP,  Cu,    In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands
- in-vitro, Lung, A549 - in-vitro, BC, MCF7 - in-vitro, Melanoma, A375 - in-vitro, Colon, HCT15 - in-vitro, Cerv, HeLa
TrxR↓, eff↓, eff↓, other∅,
1903- AgNPs,    Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen
- in-vitro, Lung, U1285
TrxR↓, eff↝, ROS↑,
4414- AgNPs,    Silver nanoparticles: Forging a new frontline in lung cancer therapy
- Review, Lung, NA
tumCV↑, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, angioG↓,
4411- AgNPs,    Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities
- in-vitro, Lung, A549 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,
4427- AgNPs,    Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells
- in-vitro, Lung, A549
tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,
4438- AgNPs,  ART/DHA,    Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer
- in-vitro, Lung, A549
EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,
4380- AgNPs,    Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways
- in-vitro, Lung, A549
ROS↑, tumCV↓, MMP↓, TumCCA↑, PCNA↓, eff↓,
4376- AgNPs,    Interaction of multi-functional silver nanoparticles with living cells
- in-vitro, Nor, L929 - in-vitro, Lung, A549
eff↑, selectivity↑,
4372- AgNPs,    Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549
TumCD↑,
4383- AgNPs,    Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies
- in-vitro, Lung, A549 - in-vivo, Lung, A549
Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,
4555- AgNPs,    Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,
4551- AgNPs,  FBZ,    Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy
- in-vivo, Lung, NA
eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,
5147- AgNPs,    Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,
327- AgNPs,  MS-275,    Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells
- in-vitro, Lung, A549
Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,
371- AgNPs,    Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549
- in-vitro, Lung, A549
ROS↑, mtDam↑,
364- AgNPs,    Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines
- in-vitro, Lung, A549 - in-vitro, Hepat, HepG2 - in-vitro, CRC, SW-620
TumCD↑,
361- AgNPs,    Annona muricata assisted biogenic synthesis of silver nanoparticles regulates cell cycle arrest in NSCLC cell lines
- in-vitro, Lung, A549
Apoptosis↑, Casp↑, TumCCA↑,
359- AgNPs,    Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,
355- AgNPs,    Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines
- in-vitro, Lung, A549 - in-vitro, NA, BEAS-2B
ROS↑, DNAdam↑, Apoptosis↑,
357- AgNPs,    Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, L132
mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,
395- AgNPs,    The apoptotic and genomic studies on A549 cell line induced by silver nitrate
- in-vitro, Lung, A549
BAX↑, MMP↓,
379- AgNPs,    Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
- in-vivo, Lung, H1299
NF-kB↓, Bcl-2↓, Casp3↑, survivin↑, TumCG↓,
7426- AgNPs,  CS,    Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation
- in-vitro, Pca, PC3 - in-vitro, Lung, A549
*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
247- AL,    Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MMP2↓, MMP9↓, TIMP1↑, TIMP2↑, p‑Akt↓, PI3K/Akt↓,
231- AL,    Molecular Docking Studies with Garlic Phytochemical Constituents to Inhibit the Human EGFR Protein for Lung Cancer Therapy
- Analysis, Lung, NA
EGFR↓, ROS↑,
5167- AL,    The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
- in-vitro, Nor, 3T3 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, CRC, HT-29
Thiols↓, tumCV↓, TumCP↓, GSH↓, GSSG↑, ROS↑,
280- ALA,    Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
- in-vivo, Lung, A549
p‑mTOR↑, TumCG↓, TumAuto↓, p‑P70S6K↑,
281- ALA,    Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
- in-vitro, Lung, H460
mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,
291- ALA,  HCA,  MET,  DFC,    Metabolic therapies inhibit tumor growth in vivo and in silico
- in-vivo, Melanoma, B16-F10 - in-vivo, Lung, LL/2 (LLC1) - in-vivo, Bladder, MBT-2
TumCG↓,
267- ALA,    α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
Apoptosis↑, ROS↑, PDK1 / PDPK1↓, NRF2↓, PDK1 / PDPK1↓, Bcl-2↓, Casp9↑, Dose∅,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT/SLC7A11↓, MMP↓, ATP↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
578- Api,  Cisplatin,    Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis
- in-vitro, Lung, A549 - in-vitro, BC, MCF7 - in-vitro, CRC, HCT116 - in-vitro, Pca, HeLa - in-vitro, Lung, H1299
p‑P53↑,
958- Api,    Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma
- in-vitro, Lung, NCIH1299
Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, PDGF↓, angioG↓,
206- Api,    Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, Melanoma, A375 - in-vitro, Lung, H2030 - in-vitro, CRC, SW480
Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,
2594- Api,  docx,    Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells
- in-vitro, Lung, A549
NRF2↓, ChemoSen↑,
1150- Api,    Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement
- in-vitro, Lung, EAhy926
eNOS↓, MMP9↓, Akt↓, p38↓, JNK↓,
1565- Api,    Apigenin-7-glucoside induces apoptosis and ROS accumulation in lung cancer cells, and inhibits PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1975
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, Cyt‑c↑, MDA↑, GSH↓, ROS↑, PI3K↓, Akt↓, mTOR↓,
1559- Api,    Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment
- in-vitro, Lung, A549 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Dose↓, selectivity↑,
3388- ART/DHA,    Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation
- in-vitro, Lung, A549 - in-vitro, Nor, GP-293 - in-vitro, BC, MDA-MB-231
NRF2↑, ROS∅,
566- ART/DHA,  2DG,    Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,
567- ART/DHA,    An Untargeted Proteomics and Systems-based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells
- in-vitro, Lung, BEAS-2B
NRF2↑, AP-1↑, NFAT↑,
2575- ART/DHA,  docx,    Artemisia santolinifolia-Mediated Chemosensitization via Activation of Distinct Cell Death Modes and Suppression of STAT3/Survivin-Signaling Pathways in NSCLC
- in-vitro, Lung, H23
ChemoSen↑, GPx4↓, ROS↑, Ferroptosis↑, eff↑,

Showing Research Papers: 1 to 50 of 398
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 398

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD47↓, 1,   DHODH↓, 1,   FBXO5/EMI1↓, 1,   HSP60/HSPD1↓, 1,   IGF-2R↑, 2,   miR-106b↓, 2,   NA↑, 2,   Nausea↓, 1,   NPL4↓, 2,   PGE3↑, 1,   PGI2↓, 1,   SUV39H↓, 2,   TBXAS1/TxAS↓, 1,   Vomit↓, 1,   WDR72↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 1,   antiOx↑, 5,   ARE/EpRE↑, 1,   ATF3↑, 1,   Catalase↓, 1,   Catalase↑, 2,   compI↓, 1,   CoQ10↑, 1,   Fenton↑, 1,   Ferroptosis↑, 8,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 7,   GSH?, 1,   GSH↓, 22,   GSH↑, 3,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 1,   GSSG↑, 1,   H2O2↑, 5,   HK1↓, 2,   HO-1↓, 5,   HO-1↑, 3,   ICD↑, 1,   Iron↑, 4,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 6,   i-MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NQO1↓, 2,   NRF2↓, 14,   NRF2↑, 6,   NRF2⇅, 2,   OXPHOS↑, 3,   Prx↓, 1,   Prx3↑, 1,   PrxII↓, 1,   RNS↓, 1,   ROS↓, 11,   ROS↑, 124,   ROS⇅, 2,   ROS∅, 1,   mt-ROS↑, 7,   selenoP↓, 1,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 2,   T-SOD↓, 1,   Thiols↓, 1,   Trx↓, 2,   Trx2↓, 1,   TrxR↓, 14,   TrxR1?, 1,   TrxR1↓, 1,   VDAC1↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   AIF↑, 1,   ATP↓, 11,   ATP⇅, 1,   CDC25↓, 1,   EGF↓, 1,   ETC↓, 1,   MEK↓, 1,   p‑MEK↓, 1,   mitResp↓, 4,   mitResp↑, 2,   MMP↓, 45,   MPT↑, 1,   mtDam↓, 1,   mtDam↑, 16,   OCR↓, 2,   OCR↑, 2,   PGC-1α↑, 1,   PHB↓, 2,   Raf↓, 1,   p‑Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   6PGD↓, 1,   Ac-histone H3↑, 1,   ACC↑, 1,   ACLY↓, 1,   AKT1↓, 2,   ALDOA↓, 1,   AMP↑, 1,   AMPK↑, 9,   BCAP↓, 1,   cMyc↓, 3,   ECAR∅, 1,   ENO1↓, 1,   FABP4↑, 1,   FASN↓, 1,   FDG↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 11,   GlutMet↓, 1,   Glycolysis↓, 11,   ac‑Histones↑, 1,   HK2↓, 7,   IDH1↓, 1,   IDO1↓, 1,   lactateProd↓, 13,   LDH↓, 3,   LDH↑, 5,   LDH∅, 1,   LDHA↓, 2,   LDHA∅, 1,   NADPH↓, 1,   NADPH↑, 1,   NPC1L1↓, 1,   PDH∅, 1,   PDK1 / PDPK1↓, 11,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 2,   PFKFB2↓, 2,   PGK1↓, 1,   PI3K/Akt↓, 2,   PKM2↓, 9,   PKM2∅, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPP↓, 2,   Pyruv↓, 1,   p‑S6↓, 1,   S6K↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   TCA↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1,   Akt↓, 40,   p‑Akt↓, 22,   Apoptosis↓, 5,   Apoptosis↑, 119,   BAD↑, 2,   p‑BAD↓, 1,   Bak↑, 1,   BAX↑, 32,   BAX↝, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 36,   Bcl-2↑, 3,   Bcl-2↝, 1,   Bcl-xL↓, 4,   Bcl-xL↑, 1,   BID↑, 4,   BIM↑, 1,   Casp↑, 7,   Casp12↑, 2,   Casp12↝, 1,   Casp2↑, 1,   Casp3↑, 49,   Casp3↝, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 9,   pro‑Casp3↓, 1,   Casp7↑, 8,   Casp8↑, 8,   Casp9↑, 22,   cl‑Casp9↓, 1,   cl‑Casp9↑, 5,   cFLIP↓, 6,   Cyt‑c↑, 24,   Cyt‑c↝, 1,   DR4↑, 1,   DR4∅, 1,   DR5↑, 4,   FADD↑, 4,   Fas↑, 2,   FasL↑, 5,   Ferroptosis↑, 8,   GranB/GZMB↓, 1,   GranB/GZMB↑, 1,   GSDMD↑, 1,   GSDME↑, 1,   Hippo↓, 1,   Hippo↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   iNOS↓, 1,   JNK↓, 3,   JNK↑, 4,   p‑JNK↑, 4,   MAPK↓, 5,   MAPK↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 4,   MDM2↓, 2,   MDM2↑, 1,   MEG3↑, 1,   miR-548ah-5p↑, 1,   Necroptosis↑, 1,   necrosis↑, 3,   NOXA↑, 2,   p27/CDKN1B↑, 2,   p38↓, 3,   p38↑, 3,   p‑p38↑, 2,   Perforin↑, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 7,   survivin↑, 1,   TRPV1?, 1,   TRPV1↑, 1,   TumCD↑, 16,   TumCD∅, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,   miR-25-5p↓, 1,   p70S6↓, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   H19↑, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 1,   HATs↑, 1,   miR-205↑, 1,   miR-218↑, 1,   other?, 1,   other↑, 4,   other↝, 7,   other∅, 1,   SETBP1↓, 1,   TLE1↓, 1,   tumCV?, 1,   tumCV↓, 41,   tumCV↑, 3,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 8,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   IRE1↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   Beclin-1/ATG6⇅, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 1,   LC3II↑, 1,   LC3s↓, 1,   LC3s↑, 2,   p62↓, 3,   p62↑, 2,   TumAuto↓, 1,   TumAuto↑, 9,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 2,   CHK1↓, 1,   p‑CHK1↑, 1,   DNAdam↑, 15,   mt-DNAdam↑, 1,   DNArepair↑, 1,   DNMT1↓, 3,   P53↓, 3,   P53↑, 18,   p‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 4,   PARP↝, 1,   cl‑PARP↑, 16,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 5,   SIRT6↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 5,   CDK4↓, 7,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 7,   cycD1/CCND1↝, 1,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   cycF↓, 1,   E2Fs↓, 1,   P21↓, 3,   P21↑, 7,   P21↝, 1,   p‑RB1↓, 1,   TAp63α↑, 1,   TumCCA↓, 2,   TumCCA↑, 62,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 2,   Axin2↓, 1,   CD133↓, 5,   CD44↓, 3,   cDC2↓, 2,   cFos↓, 1,   CLOCK↓, 1,   cMET↓, 2,   CSCs↓, 10,   CSCsMark↓, 1,   Diff↑, 2,   EMT↓, 20,   EP2↓, 1,   EpCAM↓, 1,   ERK↓, 11,   ERK↑, 1,   p‑ERK↓, 6,   p‑ERK↑, 1,   ERK5↑, 1,   FOXO1↓, 1,   FOXO3↑, 2,   Gli1↓, 2,   Gli1↝, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   HDAC↓, 7,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HH↓, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   IGF-2↑, 1,   IGFBP3↓, 1,   Let-7↑, 1,   miR-330-5p↑, 1,   miR-34a↑, 2,   mTOR↓, 14,   mTOR⇅, 1,   p‑mTOR↓, 5,   p‑mTOR↑, 1,   Nanog↓, 5,   NOTCH3↓, 1,   OCT4↓, 6,   P70S6K↓, 1,   p‑P70S6K↑, 1,   PI3K↓, 15,   p‑PI3K↓, 4,   PTEN↑, 7,   RAS?, 1,   Shh↓, 2,   SHP1↑, 1,   Smo↓, 2,   SOX2↓, 6,   Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   STAT3↑, 1,   p‑STAT3↓, 5,   mt-STAT3↓, 1,   TAZ↓, 2,   p‑TAZ↑, 1,   TumCG↓, 67,   TumCG↑, 2,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AP-1↑, 1,   ATPase↓, 1,   Ca+2↓, 1,   Ca+2↑, 8,   i-Ca+2↑, 1,   CD31/PECAM-1↑, 1,   CEA↓, 1,   circ-PRKCA↓, 1,   CLDN2↓, 1,   COL1A1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 12,   F-actin↓, 1,   Fibronectin↑, 1,   FOSB↑, 1,   FTO↓, 1,   GLI2↝, 1,   hnRNPA1↓, 1,   ITGA5↑, 1,   ITGB1↓, 2,   ITGB1↑, 1,   Ki-67↓, 8,   LAMA5↑, 1,   MARK4↓, 1,   miR-19b↓, 3,   miR-200b↑, 1,   miR-206↑, 1,   miR-384↑, 1,   miR-486↑, 1,   MMP1↓, 1,   MMP2↓, 17,   MMP2⇅, 1,   MMP3↓, 2,   MMP9↓, 17,   MMP9⇅, 1,   MMPs↓, 1,   MRGPRF↓, 1,   MUC1-C↓, 1,   N-cadherin↓, 9,   N-cadherin↑, 1,   NFAT↑, 1,   p44↓, 1,   PDGF↓, 1,   PKCδ↓, 2,   RHBDD1↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Smad1↓, 1,   p‑SMAD2↓, 5,   p‑SMAD3↓, 4,   SMAD4↓, 1,   Snail↓, 6,   Snail↑, 2,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   TregCell↓, 1,   TSC1↑, 1,   TumCI↓, 34,   TumCMig↓, 43,   TumCP?, 1,   TumCP↓, 77,   TumCP⇅, 1,   TumCP∅, 1,   TumMeta↓, 17,   TXNIP↑, 1,   uPA↓, 2,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   ZO-1↑, 3,   α-tubulin↓, 1,   α-tubulin↑, 2,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   ATF4↑, 2,   ECM/TCF↓, 1,   EGFR↓, 17,   p‑EGFR↓, 1,   eNOS↓, 1,   EPR↑, 3,   Hif1a↓, 14,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 11,   VEGFR2/KDR/Flk1↓, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   CTR1↑, 1,   GLUT1↓, 9,   GLUT1∅, 1,   GLUT3∅, 1,   GLUT4↓, 1,   P-gp/ABCB1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 2,   CD4+↑, 1,   cellSen↑, 1,   COX2/PTGS2↓, 9,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCR2↑, 1,   FOXP3↓, 1,   HMGB1↓, 3,   IFN-γ↑, 2,   Igs↓, 1,   IKKα↑, 2,   IL1↑, 2,   IL10↓, 2,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 4,   IL6↑, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 5,   Inflam↑, 1,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 5,   pol-M1↝, 1,   M2 MC↑, 1,   MDSCs↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 22,   NF-kB↑, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 2,   p50↓, 1,   p65↓, 2,   p‑p65↑, 1,   PD-L1↓, 10,   PD-L1↑, 3,   PDT+↓, 1,   PGE2↓, 2,   T-Cell↑, 4,   TLR1↑, 1,   TLR2↑, 1,   TLR4↑, 1,   TNF-α↓, 5,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 3,   BioAv↑, 6,   ChemoSen↓, 1,   ChemoSen↑, 35,   ChemoSen⇅, 1,   ChemoSen∅, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 2,   Dose↝, 37,   Dose∅, 8,   eff↓, 39,   eff↑, 68,   eff↝, 7,   Half-Life↓, 2,   Half-Life↝, 3,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 13,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 53,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CA125↓, 1,   CEA↓, 1,   CYFRA21-1↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 17,   p‑EGFR↓, 1,   Ferritin↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   IL6↑, 1,   Ki-67↓, 8,   LDH↓, 3,   LDH↑, 5,   LDH∅, 1,   PD-L1↓, 10,   PD-L1↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   antiNeop↑, 1,   AntiTum↑, 6,   AntiTum⇅, 1,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 5,   ChemoSideEff↓, 1,   ChemoSideEff∅, 1,   cognitive↑, 1,   hepatoP↑, 1,   NKG2D↑, 1,   OS?, 1,   OS↑, 7,   OS∅, 2,   Pain↓, 1,   QoL↑, 4,   radioP↑, 2,   Remission↑, 2,   RenoP↑, 1,   Risk↓, 2,   Risk⇅, 1,   Risk↝, 1,   Sleep↑, 1,   toxicity↓, 7,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 15,   TumVol⇅, 1,   TumW↓, 8,   TumW⇅, 1,   Weight?, 1,   Weight↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   CD8+↑, 3,  
Total Targets: 645

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 2,   GPx↓, 1,   GPx↑, 2,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 3,   Prx↑, 1,   ROS↓, 4,   i-ROS↑, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↝, 1,   Apoptosis↓, 1,   p‑JNK↓, 1,   MAPK↝, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

TREM-1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↝, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   i-Ca+2↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   GM-CSF↑, 1,   IL4↓, 1,   IL6↓, 1,   Inflam↓, 3,   IP-10/CXCL-10↑, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioEnh↑, 1,   Dose↝, 1,   Half-Life∅, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   toxicity?, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 6,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 54

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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