BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱

Source:

Type:

Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.

MB, Medulloblastoma: Click to Expand ⟱

Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults.
Activation of these three pathways Akt/NF-kB, Shh, and Wnt/b-catenin converge in the upregulation of C-myc, N-myc, and Cyclin D1, three oncoproteins that play key roles in the development of medulloblastomas. High levels of these three oncoproteins were considered to be bad prognosis because they are related to unfavorable therapeutic outcome.

Scientific Papers found: Click to Expand⟱

6253-

CBC/D,

The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma

Review,

MB,

Gli1↓, Dose↝, HH↓, BBB↑,

7302-

GlaB,

Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma

vitro+vivo,

MB,

BioAv↑, Gli1↓, TumCG↓, Dose↝, BBB↑, HH↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 2, HH↓, 2, TumCG↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, Dose↝, 2,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells