NOTCH3 Cancer Research Results

NOTCH3, Notch homolog 3: Click to Expand ⟱
Source:
Type:
NOTCH3 is a member of the Notch signaling pathway, which plays a crucial role in cell communication, development, and differentiation.
NOTCH3 can have both oncogenic (cancer-promoting) and tumor-suppressive roles, depending on the type of cancer and the cellular context.
Overexpression in: breast, ovarian, lung, head and neck, gbm, pancreatic.
NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
Scientific Papers found: Click to Expand⟱
6845- EVO,    Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, H1299
AntiCan↑, TumVol↓, NOTCH3↓, tumCV↓, TumCCA↑, TumCMig↓, CSCs↓, TumCP↓, Apoptosis↑, TumCI↓, ROS↑, TumCG↓, selectivity↑, DNMT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   NOTCH3↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NOTCH3, Notch homolog 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:19  Cells:%  prod#:%  Target#:437  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page