CD11b Cancer Research Results

CD11b, CD11b: Click to Expand ⟱
Source:
Type:
CD11b’s (also known as integrin αM or ITGAM).
Markers CD14 and CD11b is one of the important characteristics of differentiation.

High levels of CD11b are often noted in the tumor microenvironment.
A high density of CD11b⁺ cells in the tumor microenvironment has been associated with adverse prognosis. For example, an abundance of MDSCs (which are CD11b⁺) is linked to immunosuppression, tumor progression, and resistance to therapies. High levels of CD11b⁺ cell infiltration have been correlated with:
-Faster tumor progression.
-Increased metastasis.
-Reduced response to immunotherapies.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7183- CHA,    The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells
- in-vitro, AML, HL-60 - in-vitro, AML, KG-1 - in-vitro, lymphoma, U937
TumCD↓, SUV39H↓, CD11b↑, Diff↑, H3K9↓, eff↑,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

H3K9↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↑, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

TumCD↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 2,  

Migration(tgid=13) ⓘ

CD11b↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CD11b, CD11b
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:1067  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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