TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.


AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia

Scientific Papers found: Click to Expand⟱
5341- Ajoene,    Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy
- Review, AML, NA
eff↑, AntiThr↑, Bacteria↓, LDH↓, TumCP↓, TumCCA↑, Bcl-2↓, Cyt‑c↑, Casp3↑,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
5129- ART/DHA,    Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds
- in-vitro, AML, HL-60
Casp↑, Apoptosis↑, MMP↓, TumCCA↑, eff↑, eff↑,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
5687- BJ,    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
- vitro+vivo, AML, U937
Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,
5692- BJ,    Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells
- vitro+vivo, AML, NA
Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,
5944- Cela,    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
- in-vitro, AML, U937
TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,
7166- CHA,    Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1
- vitro+vivo, AML, U937
SUV39H↓, Apoptosis↑, ROS↑, TumCCA↑, tumCV↓, Casp3↑, Casp9↑, Fas↑, FasL↑, DR4↑, P21↑, eff↓, eff↑,
7449- CYN,    Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines
- in-vitro, lymphoma, U937 - in-vitro, AML, Jurkat
TumCP↓, selectivity↑, Apoptosis↑, TumCCA↑, DNAdam↑, eff↓, ROS↑, tumCV↓,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6585- EU,    Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
- vitro+vivo, AML, K562
Dose↝, TumCG↓, Apoptosis↑, TumCCA↑, DNAdam↑, Akt↓, Bcl-2↓, PCNA↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,
2080- HNK,    Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
- in-vitro, AML, THP1 - in-vitro, AML, U937 - in-vitro, AML, SK-HEP-1
tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,
1931- TQ,  doxoR,    Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
- in-vivo, AML, NA
eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0)

SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1)

Ferroptosis↑, 1,   GPx4∅, 1,   HO-1↑, 1,   lipid-P↑, 1,   ROS↑, 6,   i-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3)

ATP↓, 1,   mitResp↓, 1,   MMP↓, 4,   mtDam↑, 1,   OCR↓, 1,   XIAP↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

ACLY↓, 1,   AMPK↑, 1,   cMyc↓, 1,   ECAR↑, 1,   FASN↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↓, 1,  

Cell Death(tgid=5)

Akt↓, 3,   Apoptosis↑, 9,   mt-Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 2,   Casp3↑, 5,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 3,   Cyt‑c↑, 3,   DR4↑, 1,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   Myc↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7)

AntiThr↑, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↑, 2,   eIF2α↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9)

p62↑, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↑, 6,   P53↑, 2,   PARP↓, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11)

CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 4,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12)

CSCs↓, 1,   FOXO1↑, 1,   GSK‐3β↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PI3K↓, 1,   STAT3↓, 2,   TumCG↓, 3,  

Migration(tgid=13)

ATPase↓, 1,   FAK↓, 1,   Ki-67↓, 1,   MMPs↓, 1,   TumCP↓, 5,   TumMeta↓, 1,   TXNIP↑, 1,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 1,   ATF4↑, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15)

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16)

Imm↑, 1,   NF-kB↓, 1,  

Hormonal & Nuclear Receptors(tgid=20)

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 3,   eff↓, 3,   eff↑, 9,   eff↝, 2,   Half-Life↓, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22)

Ki-67↓, 1,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 1,   OS↑, 1,   QoL↑, 1,   TumVol↓, 2,  

Infection & Microbiome(tgid=24)

Bacteria↓, 1,  
Total Targets: 104

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 2,   ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

Inflam↓, 2,  

Functional Outcomes(tgid=23)

hepatoP↑, 2,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
2 Brucea javanica
1 Ajoene (compound of Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Artemisinin
1 Biochanin A
1 Betulinic acid
1 Capsaicin
1 Celastrol
1 chaetocin
1 Cynaropicrin
1 Dandelion Root
1 Eurycomanone
1 Gallic acid
1 HydroxyCitric Acid
1 Honokiol
1 Thymoquinone
1 doxorubicin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:322  State#:%  Dir#:2
wNotes=0 sortOrder:rid,rpid

 

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