Cancer Database Query Results

AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7703- ,    Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation
- in-vitro, AML, PLB-985
TumCG↓, TumCD↑, Diff↑, NOX2↑, ROS↑,
6838- ,    Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
- in-vitro, AML, K562
TumCP↓, TOP1↓, TOP2↓,
6476- 1,8-Cin,    Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line
- in-vitro, AML, NA
TumCG↓, selectivity↑, Apoptosis↑,
4428- AgNPs,    p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells
- in-vitro, AML, Jurkat
toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,
4375- AgNPs,    The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells
- in-vitro, AML, K562
eff↑, ROS↑, Apoptosis↑, eff↓,
5340- Ajoene,    Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB
- in-vitro, AML, NA
Apoptosis↑, selectivity↑, H2O2↑, NF-kB↑,
5341- Ajoene,    Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy
- Review, AML, NA
eff↑, AntiThr↑, Bacteria↓, LDH↓, TumCP↓, TumCCA↑, Bcl-2↓, Cyt‑c↑, Casp3↑,
252- Ajoene,    Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB
- in-vitro, AML, HL-60
H2O2↑, NF-kB↑, ROS↑,
5165- AL,    The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
- in-vitro, AML, Jurkat - in-vitro, Nor, L929
necrosis↑, Thiols↓, GSH↓, ENO1↓, Zn2+↑, Glycolysis↓, ATP↓, BioAv↓,
6601- Anamu,    Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model
- in-vitro, AML, NA
AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
591- Api,  doxoR,    Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
- in-vitro, AML, Jurkat - in-vitro, AML, THP1
ATP↓, Casp3↑, γH2AX↑,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
269- Api,    Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, AML, TF1
JAK↓, PI3K↓, cDC2↓, STAT↓,
268- Api,    Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
- in-vitro, AML, HL-60
Casp3↑, PARP↑,
1148- ART/DHA,    Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
- in-vitro, AML, THP1
MMP9↓, EMMPRIN↓, p‑PKCδ↓, p‑JNK↓, p‑p38↓, p‑ERK↓,
5377- ART/DHA,    Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein
- in-vitro, AML, NA
AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, eff↑, other↓, eff↑, other↓,
5129- ART/DHA,    Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds
- in-vitro, AML, HL-60
Casp↑, Apoptosis↑, MMP↓, TumCCA↑, eff↑, eff↑,
4992- ART/DHA,    Dihydroartemisinin Increases the Sensitivity of Acute Myeloid Leukemia Cells to Cytarabine via the Nrf2/HO-1 Anti-Oxidant Signaling Pathway
- in-vitro, AML, HL-60
Apoptosis↑, Diff↑, ROS↓, HO-1↓, NRF2∅,
2320- ART/DHA,    Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis
- in-vitro, AML, K562 - in-vitro, Liver, HepG2
Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, PKM2↓, ECAR↓, LDHA↓, cMyc↓, other↝,
2572- ART/DHA,  SRF,    Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax
- in-vitro, AML, NA
CHOP/DDIT3↑, Mcl-1↓, ChemoSen↑, selectivity↑,
2580- ART/DHA,  VitC,    Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-4 Human Leukemia Cells
- in-vitro, AML, NA
eff↓, other↝, ROS↑, eff↓, eff↓,
2581- ART/DHA,  PB,    Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells
- in-vitro, AML, NA
eff↑, selectivity↑,
1371- Ash,    Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine
- in-vitro, AML, HL-60
ROS↑, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, eff↓,
5370- AV,    The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial
- Trial, AML, NA
Dose↝, stomatitis↓, Pain↓,
1526- Ba,    Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, cl‑PARP↑, DNAdam↑, cl‑BID↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9?, H2O2↑, ROS↑,
5544- BBM,    Berbamine promotes macrophage autophagy to clear Mycobacterium tuberculosis by regulating the ROS/Ca2+ axis
- in-vitro, AML, THP1
ROS↑, Ca+2↑,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
5687- BJ,    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
- vitro+vivo, AML, U937
Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,
5692- BJ,    Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells
- vitro+vivo, AML, NA
Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,
707- Bor,    Cytotoxic and apoptotic effects of boron compounds on leukemia cell line
- in-vitro, AML, HL-60
Apoptosis↑,
1421- Bos,    Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes
- in-vitro, AML, HL-60 - in-vitro, Nor, NA
ROS↑, NADPH↝, 5LO↓, Ca+2↑, p38↑, p42↑,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
7967- BUL,    Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin
- in-vivo, Ovarian, A2780S - in-vivo, AML, L1210
compI↓, ETC↓,
7972- BUL,    Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes
- vitro+vivo, Cerv, HeLa - vitro+vivo, AML, HL-60
NADH↓, selectivity↑,
7977- BUL,    Mitochondria-mediated apoptosis induced by acetogenins from Porcelia macrocarpa (Annonaceae) in K562 chronic myeloid leukemia cells
- in-vitro, AML, K562
compI↓, tumCV↓, SOD2↑, MMP↓, Ca+2↝, Casp3↑, Casp9↑,
5867- CA,    Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines
- in-vitro, Pca, DU145 - in-vitro, Liver, Hep3B - in-vitro, AML, K562 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCP↓, eff↑, other↝,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,
5922- Cats,    Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB
- in-vitro, AML, THP1
NF-kB↓, AP-1↓, TNF-α↓,
5915- Cats,    Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells
- in-vitro, AML, NA
Apoptosis↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5944- Cela,    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
- in-vitro, AML, U937
TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,
7183- CHA,    The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells
- in-vitro, AML, HL-60 - in-vitro, AML, KG-1 - in-vitro, lymphoma, U937
TumCD↓, SUV39H↓, CD11b↑, Diff↑, H3K9↓, eff↑,
7186- CHA,  TSA,    Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
- in-vitro, AML, NA
SUV39H↓, H3K9↓, eff↑,
7166- CHA,    Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1
- vitro+vivo, AML, U937
SUV39H↓, Apoptosis↑, ROS↑, TumCCA↑, tumCV↓, Casp3↑, Casp9↑, Fas↑, FasL↑, DR4↑, P21↑, eff↓, eff↑,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
7415- CS,    Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells
- in-vitro, AML, THP1
AKR1B10↓, NF-kB↓, COX2/PTGS2↓, MMP2↓, ROS↓,
481- CUR,  CHr,  Api,    Flavonoid-induced glutathione depletion: Potential implications for cancer treatment
- in-vitro, Liver, A549 - in-vitro, Pca, PC3 - in-vitro, AML, HL-60
GSH↓, mtDam↑, MMP↓, Cyt‑c↑,

Showing Research Papers: 1 to 50 of 150
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 150

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AKR1B10↓, 1,   H3K9↓, 2,   IGF2BP3/IMP3/KOC↓, 1,   K+↑, 1,   NOX2↑, 1,   SUV39H↓, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   compI↓, 2,   Fenton↑, 1,   Ferroptosis↑, 3,   GPx↑, 1,   GPx4∅, 1,   GSH↓, 6,   GSH↝, 1,   GSH/GSSG↓, 2,   H2O2↑, 5,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   Mets↑, 1,   NADH↓, 1,   NRF2↓, 4,   NRF2↑, 1,   NRF2∅, 1,   p‑NRF2↓, 1,   Prx↓, 2,   Prx6↑, 1,   ROS↓, 5,   ROS↑, 45,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD2↑, 1,   TBARS↑, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   AIF↑, 2,   ATP↓, 4,   BCR↓, 1,   ETC↓, 1,   p‑MEK↑, 1,   mitResp↓, 1,   MMP↓, 20,   mtDam↑, 4,   OCR↓, 1,   p42↑, 1,   Raf↓, 1,   XIAP↓, 3,   XIAP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   cMyc↓, 2,   DHCR24↑, 1,   ECAR↓, 1,   ECAR↑, 1,   ENO1↓, 1,   FASN↓, 2,   FBP1↑, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   HMG-CoA↓, 1,   lactateProd↓, 4,   LDH↓, 3,   LDHA↓, 1,   NADPH↑, 1,   NADPH↝, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   PPP↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 10,   p‑Akt↓, 1,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 49,   mt-Apoptosis↑, 1,   BAX↑, 16,   Bax:Bcl2↑, 4,   Bcl-2↓, 17,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   cl‑BID↑, 2,   Casp↑, 7,   cl‑Casp1↓, 1,   Casp3↑, 27,   cl‑Casp3↑, 4,   proCasp3↑, 1,   Casp7↑, 2,   Casp8↑, 12,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 14,   cl‑Casp9↑, 2,   proCasp9↑, 2,   CK2↓, 1,   Cyt‑c↑, 15,   Diablo↑, 2,   DR4↑, 3,   DR5↑, 1,   Fas↑, 6,   FasL↑, 3,   Ferroptosis↑, 3,   IAP1↓, 3,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   iNOS↓, 2,   JNK↑, 3,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 5,   cl‑Mcl-1↑, 1,   MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   MOMP↑, 1,   Myc↓, 2,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↑, 5,   p‑p38↓, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 2,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 10,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,   Sp1/3/4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   other↓, 2,   other↑, 2,   other↝, 6,   tumCV↓, 21,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 2,   ER Stress↑, 2,   HSP70/HSPA5↑, 4,   HSP90↓, 2,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LC3I↓, 1,   LC3I↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 14,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   G9a↓, 1,   P53↓, 1,   P53↑, 8,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 13,   PARP1↑, 1,   PCNA↓, 1,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↑, 6,   RB1↓, 1,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,   CSCs↓, 4,   Diff↑, 6,   ERK↑, 1,   p‑ERK↓, 3,   p‑ERK↑, 2,   FLT3↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC4↓, 2,   HMGCR↑, 1,   HRAS↓, 1,   mTOR↓, 4,   mTOR↑, 1,   NRAS↓, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 3,   STAT3↑, 1,   TOP1↓, 1,   TOP1↑, 2,   TOP2↓, 1,   TOP2↑, 2,   TumCG↓, 18,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 1,   AP-1↓, 1,   ATPase↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   CC(CDKs/cyclins)↑, 1,   CD11b↑, 2,   i-Chl↑, 1,   DLC1↑, 1,   EMMPRIN↓, 1,   FAK↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   miR-133a-3p↑, 1,   miR-155↓, 1,   miR-206↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   Na+↑, 1,   p‑PKCδ↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 21,   TumMeta↓, 2,   TXNIP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 2,   EPR↑, 1,   Hif1a↓, 2,   NO↑, 1,   nucleolin↑, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   BBB↝, 1,   CellMemb↑, 1,   GLUT1↓, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   COX2/PTGS2↓, 4,   DCells↓, 1,   IKKα↓, 2,   IL1↓, 1,   IL10↑, 1,   IL1β↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 2,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   M1↑, 1,   M2 MC↑, 1,   NF-kB↓, 12,   NF-kB↑, 3,   NF-kB↝, 1,   p50↓, 1,   p65↓, 1,   PD-L1↓, 1,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 6,   Dose?, 1,   Dose↑, 1,   Dose↝, 14,   eff↓, 17,   eff↑, 34,   eff↝, 3,   Half-Life↓, 1,   selectivity?, 1,   selectivity↑, 24,   selectivity∅, 1,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   Ki-67↓, 1,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 2,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiP↑, 1,   AntiTum↑, 2,   cardioP↑, 1,   chemoPv↑, 3,   neuroP↑, 1,   OS↑, 3,   Pain↓, 1,   QoL↑, 2,   Remission↑, 2,   stomatitis↓, 1,   Strength↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 333

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Ingr↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   RNS↓, 1,   ROS↓, 2,   ROS↑, 2,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 6,   NF-kB↓, 1,   TNF-α↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 2,   hepatoP↑, 2,   neuroP↑, 2,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 15

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page