CXCL6/GCP-2 Cancer Research Results

CXCL6/GCP-2, C-X-C Motif Chemokine Ligand: Click to Expand ⟱
Source:
Type:

CXCL6 - C-X-C Motif Chemokine Ligand 6

Abbreviation: CXCL6, GCP-2

Type: Chemokine / inflammatory cytokine

Function: Pro-inflammatory CXC chemokine that signals primarily through CXCR1 and CXCR2. CXCL6 promotes neutrophil recruitment and activation and regulates inflammation, angiogenesis, cell migration, and interactions between tumor cells, stromal cells, and immune cells within the tumor microenvironment.

Cancer: ↑ Frequently increased or overactivated in cancer. CXCL6/CXCR1/2 signaling can promote tumor-cell proliferation, migration, invasion, angiogenesis, neutrophil recruitment, metastatic progression, and development of a tumor-supportive inflammatory microenvironment. Elevated CXCL6 has been associated with aggressive behavior and poorer outcomes in several malignancies.
Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   TYMP/ECGF1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CXCL6/GCP-2, C-X-C Motif Chemokine Ligand
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:1637  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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