miR-375 Cancer Research Results

miR-375, miR-375: Click to Expand ⟱
Source:
Type:

miR-375 is a regulatory microRNA that generally functions as a tumour suppressor in head-and-neck and HPV-associated squamous cell carcinomas. It can suppress oncogenic transcripts involved in proliferation, survival, invasion, and extracellular-matrix degradation, including AEG-1/MTDH, IGF1R, JAK2, and YAP1. miR-375 may also directly or indirectly reduce HPV16/18 E6 and E7 expression, thereby supporting p53 and RB tumour- suppressor activity. miR-375 is frequently downregulated in these cancers; therefore, restoration or increased expression is generally considered the favourable direction in this context. Effects may differ by cancer type.



Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGFR↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-375, miR-375
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:1522  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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