DJ-1 Cancer Research Results

DJ-1, DJ-1: Click to Expand ⟱
Source:
Type:
DJ-1 (also known as PARK7)
Elevated levels of DJ-1 have been observed in tumors and are often correlated with more advanced disease stages. Overexpression of DJ-1 may contribute to cell proliferation and invasion, leading to an overall poorer prognosis.

– DJ-1 functions as an oxidative stress sensor. Under conditions of increased ROS, DJ-1 undergoes specific oxidative modifications that can alter its structure and function. This allows DJ-1 to participate in protective responses against ROS-induced cellular damage. DJ-1 indirectly reduces the generation of excessive ROS and the resulting oxidative damage.
-In the context of cancer, increased DJ-1 expression can help tumor cells evade the detrimental effects of ROS, contributing to resistance against oxidative stress–inducing therapies.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

DJ-1↓, 1,   ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DJ-1, DJ-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:1069  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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