Thiols Cancer Research Results

Thiols, Thiols: Click to Expand ⟱

Source:

Type:

"Thiols" generally refer to compounds containing sulfhydryl (–SH) groups, with glutathione (GSH) being one of the most abundant and well-studied cellular thiols. Thiol groups play essential roles in maintaining redox balance, detoxifying reactive oxygen species (ROS), and modulating protein function via post-translational modifications.

• Elevated levels of glutathione and related thiols have been associated with enhanced resistance to chemotherapy and radiation, as these treatments often work by inducing oxidative damage.

PC, Pancreatic Cancer: Click to Expand ⟱

Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑

Scientific Papers found: Click to Expand⟱

7452-

CYN,

Cynaropicrin inhibits pancreatic cancer cell viability and disrupts cellular redox homeostasis

in-vitro,

PC,

PANC1

tumCV↓, Thiols↓, NF-kB↓, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1, Thiols↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Thiols, Thiols

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells