BACE Cancer Research Results
BACE, β-site APP-cleaving enzyme: Click to Expand ⟱
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BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.
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PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
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Scientific Papers found: Click to Expand⟱
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vitro+vivo, |
PC, |
MIA PaCa-2 |
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TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE↓, TOP2↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, cl‑Casp3↑, 1,
Cell Cycle & Senescence ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TOP2↓, 1, TumCG↓, 1,
Migration ⓘ
MMP2↓, 1, TumCI↓, 1,
Protein Aggregation ⓘ
BACE↓, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: BACE, β-site APP-cleaving enzyme
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:21 Cells:% prod#:% Target#:1349 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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